Results 171 to 180 of about 29,106 (245)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Neutron capture measurements for s-process nucleosynthesis: A review about CERN n_TOF developments and contributions. [PDF]

Eur Phys J A Hadron Nucl
Domingo-Pardo C, Aberle O, Alcayne V, Alpar G, Halabi MA, Amaducci S, Babiano V, Bacak M, Balibrea-Correa J, Bartolomé J, Bernardes AP, Gameiro BB, Berthoumieux E, Beyer R, Birch M, Boromiza M, Bosnar D, Brusasco B, Caamaño M, Cahuzac A, Calviño F, Calviani M, Cano-Ott D, Casanovas A, Castelluccio DM, Catlett D, Cerutti F, Cescutti G, Chiaveri E, Claps G, Colombetti P, Colonna N, Camprini PC, Cortés G, Cortés-Giraldo MA, Cosentino L, Cristallo S, D'Ottavi A, de la Fuente Rosales G, Dellmann SF, Diakaki M, Di Castro M, Di Chicco A, Dietz M, Dupont E, Durán I, Eleme Z, Eslami M, Fargier S, Fernández-Domínguez B, Finocchiaro P, Flanagan W, Furman V, Gandhi A, García-Infantes F, Gawlik-Ramiega A, Gervino G, Gilardoni S, González-Romero E, Goula S, Griesmayer E, Guerrero C, Gunsing F, Gustavino C, Heyse J, Hillman W, Jenkins DG, Jericha E, Junghans A, Kadi Y, Kaperoni K, Kelly I, Kokkoris M, Kopatch Y, Krtička M, Kyritsis N, Lederer-Woods C, Lerendegui-Marco J, Manna A, Martínez T, Martínez-Cañada M, Masi A, Massimi C, Mastinu P, Mastromarco M, Maugeri EA, Mazzone A, Mendoza E, Mengoni A, Michalopoulou V, Milazzo PM, Moldenhauer J, Mucciola R, González EM, Musumarra A, Negret A, Odusina E, Papanikolaou D, Patronis N, Pavón-Rodríguez JA, Pellegriti MG, Pérez-Maroto P, de Rada Fiol AP, Perfetto G, Perkowski J, Petrone C, Pieretti N, Piersanti L, Pirovano E, Porras I, Praena J, Quesada JM, Reifarth R, Rochman D, Romanets Y, Rooney A, Rovira G, Rubbia C, Sánchez-Caballero A, Sahoo RN, Scarpa D, Schillebeeckx P, Smith AG, Sosnin NV, Spelta M, Stamati ME, Stasiak K, Tagliente G, Tarifeño-Saldivia A, Tarrío D, Torres-Sánchez P, Tosi S, Tsiledakis G, Valenta S, Vaz P, Vecchio G, Vescovi D, Vlachoudis V, Vlastou R, Wallner A, Weiss C, Woods PJ, Wright T, Wu R, Žugec P, The n_TOF Collaboration.   +145 more
europepmc   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Predicting the diversity of photosynthetic light-harvesting using thermodynamics and machine learning. [PDF]

PLoS Comput Biol
Gray C, Chitnavis S, Buja T, Duffy CDP.
europepmc   +1 more source

The Evolution of Star Clusters [PDF]

Monthly Notices of the Royal Astronomical Society, 1970
openaire   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Status of the ΛCDM theory: supporting evidence and anomalies. [PDF]

Philos Trans A Math Phys Eng Sci
Peebles PJE.
europepmc   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Stellar structure via truncated M-fractional Lane-Emden solutions. [PDF]

Sci Rep
Nouh MI, Abdel-Salam EA, Hassaballa AA, Awad AM, Jazmati MS, Bahgat MSM.   +5 more
europepmc   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source