Results 221 to 230 of about 2,858,112 (243)

High-Pressure Structural Evolution of Na₂ZrSi₂O₇ and Na₂ZrSi₂O₇·H₂O: Topology-Driven Compression Behaviors, Phase Stability, and Electronic Transitions. [PDF]

Inorg Chem
Zhang P, Botella P, Bura N, Dong X, Popescu C, Raghavendra Y, Shukla R, Achary SN, Errandonea D.   +8 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Comparative anatomy of the thoracic muscles of bees (Hymenoptera: Apoidea). [PDF]

PeerJ
Meira OM, Almeida EAB.
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

The evolution of ABC star polymers: from trial-and-error to rational design. [PDF]

RSC Adv
Kalina M, Nouri B, Almdal K.
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Gastrointestinal metastasis in prostate cancer and therapeutic implications: A case report. [PDF]

Oncol Lett
Audisio MA, Nguyen AT, Peroux E, Lamboley JL, Lussato D, Pautas M, Picchi H, Le Roy A, Barhli A, Dusaud M, Vanquaethem H, Schernberg A, Helissey C.   +12 more
europepmc   +1 more source

Holocene pollen and phytolith dataset from the Xinglong site in the Bashang Grassland, northern China. [PDF]

Data Brief
Wang G, Qiu Z, Zhuang L, Rao H, Yang Z, Liu W.   +5 more
europepmc   +1 more source

Fundamentals of Interior Modelling and Challenges in the Interpretation of Observed Rocky Exoplanets. [PDF]

Space Sci Rev
Baumeister P, Miozzi F, Guimond CM, Steinmeyer ML, Dorn C, Karato SI, Bolmont É, Revol A, Thamm A, Noack L.   +9 more
europepmc   +1 more source

LG-H-PPO: offline hierarchical PPO for robot path planning on a latent graph. [PDF]

Front Robot AI
Han X.
europepmc   +1 more source