Results 41 to 50 of about 29,106 (245)
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
EVOLUTION OF NUCLEAR STAR CLUSTERS [PDF]
The Astrophysical Journal, 2009 Two-body relaxation times of nuclear star clusters are short enough that gravitational encounters should substantially affect their structure in 10 Gyr or less. In nuclear star clusters without massive black holes, dynamical evolution is a competition between core collapse, which causes densities to increase, and heat input from the surrounding galaxy,
openaire +2 more sources
The Evolution of AGB Stars [PDF]
Highlights of Astronomy, 1992 Computations of AGB stellar evolution which include the effects of mass loss are still relatively rare. However, in order to relate numbers of Mira variables, OH/IR stars and carbon stars to associated stellar populations, it is necessary to understand evolutionary timescales on the AGB.The dominant factors controlling very late AGB evolution are shell
Peter R. Wood, E. Vassiliadis
openaire +2 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Bipolar outflows and the evolution of stars [PDF]
New Astronomy Reviews, 1999 44 pages, 16 figures, to appear the New Astronomy Reviews. Figures may also be obtained at ftp://alethea.pas.rochester.edu/afrank/BPR/
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FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Stellar Evolution and Modelling Stars [PDF]
, 2017 In this chapter I give an overall description of the structure and evolution of stars of different masses, and review the main ingredients included in state-of-the-art calculations aiming at reproducing observational features. I give particular emphasis to processes where large uncertainties still exist as they have strong impact on stellar properties ...
openaire +5 more sources