Results 61 to 70 of about 3,302 (168)

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Restoration of Non-Uniform Motion-Blurred Star Images Based on Dynamic Strip Attention. [PDF]

J Imaging
Han J, Niu Z, He J.
europepmc   +1 more source

Determination of Gene‐Level Fitness Contributions Across the Mucin‐Utilization Network of Bacteroides thetaiotaomicron

Advanced Science, EarlyView.
Genome‐wide CRISPRi and RNA‐seq resolve how B. thetaiotaomicron converts host mucosal glycans into fitness. The study reveals a layered mucin‐utilization architecture in which capsular polysaccharides constrain surface access, extracellular CAZymes and peptidases show functional redundancy, and intracellular catabolic pathways create discrete metabolic
Kangsan Kim, Jiwon Lee, Minjeong Kang, Sung Sun Yim, Donghui Choe, Byung‐Kwan Cho   +5 more
wiley   +1 more source

Morphological Characterization and Complete Mitochondrial Genome of a New Epizoic Hexamerous Brittle Star <i>Gymnolophus sexradia</i> sp. Nov. [PDF]

Ecol Evol
Zhang Z, Xiao W, Zhang C, Li C, Zhang H, Chen Z.   +5 more
europepmc   +1 more source

Re‐Thinking Electronic Circuit Design Through Emerging Reconfigurable Field Effect Transistors

Advanced Science, EarlyView.
Graphical illustration of reconfigurable field effect transistor (RFET) operation modes, including n‐type, p‐type, and ambipolar transport, as well as their areas of application discussed in this review: digital circuit design, analog circuit design, post‐Shannon computing, and sensing. ABSTRACT Reconfigurable field‐effect transistors, short RFETs, are
Jens Trommer, Juan P. Martinez, Yuxuan He, Giulio Galderisi, Katrin Pingen, Eduardo Sergio Oliveros‐Mata, Lisa Tellis, Cigdem Cakirlar, Christoph Beyer, Brojogopal Sapui, Joachim Knoch, Klaus Hofmann, Sandro Carrara, Eugenio Cantatore, Max C. Lemme, Ian O'Connor, Akash Kumar, Andre Heinzig, Thomas Mikolajick, Walter M. Weber   +19 more
wiley   +1 more source

Evaluating the adaptive hypothesis of A-to-I RNA editing in filamentous ascomycete fungi. [PDF]

Mol Biol Evol
Li J, Jiang D, Zhang J.
europepmc   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Corrugator Supercilii Muscle and Its Relationship with Neurovascular Structures of the Frontal Region: A Cadaveric Study. [PDF]

Aesthetic Plast Surg
Yildiz N, Nteli Chatzioglou G, Coşkun O, Kale A, Gayretli Ö.   +4 more
europepmc   +1 more source

Product‐Reshaped Gas‐Phase Hydrodynamics Govern CO2 Electrolysis in Gas Diffusion Electrodes

Advanced Science, EarlyView.
In gas‐fed CO2${\rm CO}_2$ electrolysers, the gas phase is part of the electrochemical response. As gaseous products form, they change gas composition and flow, which in turn affects CO2${\rm CO}_2$ delivery and CO intermediate availability. This feedback changes the reaction environment needed for multicarbon formation, becoming unavoidable as ...
Abdullah A. Alyahya, Mayra S. Tovar‐Oliva, Blessings G. Malimusi, Sebastián Murcia‐López, María Escudero‐Escribano, Timm Krüger, Ignacio Tudela   +6 more
wiley   +1 more source

Association between fibroblast growth factor 23 and coronary artery calcification in patients with chronic kidney disease: a meta-analysis. [PDF]

Front Endocrinol (Lausanne)
Yi Y, Zhao Y, Wang H, Jiang X, Xuan Y.
europepmc   +1 more source