Results 31 to 40 of about 169 (167)
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
The young star cluster system in the Antennae: evidence for a turnover in the luminosity function [PDF]
Monthly Notices of the Royal Astronomical Society, 2007 The luminosity functions (LFs) of star cluster systems (i.e. the number of clusters per luminosity interval) are vital diagnostics to probe the conditions of star cluster formation. Early studies have revealed a clear dichotomy between old globular clusters and young clusters, with the former characterised by Gaussian-shaped LFs, and the latter ...
Anders, P. +4 more
openaire +2 more sources
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
THE NEAR-ULTRAVIOLET LUMINOSITY FUNCTION OF YOUNG, EARLY M-TYPE DWARF STARS [PDF]
The Astrophysical Journal, 2014 Planets orbiting within the close-in habitable zones of M dwarf stars will be exposed to elevated high-energy radiation driven by strong magneto-hydrodynamic dynamos during stellar youth. Near-ultraviolet (NUV) irradiation can erode and alter the chemistry of planetary atmospheres, and a quantitative description of the evolution of NUV emission from M ...
Megan Ansdell +10 more
openaire +4 more sources
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
On the determination of age and mass functions of stars in young open star clusters from the analysis of their luminosity functions [PDF]
Monthly Notices of the Royal Astronomical Society, 2004 Based on the CCD observations of remote young open clusters NGC 2383, NGC 2384, NGC 4103, NGC 4755, NGC 7510 and Hogg 15, we constructed their observed luminosity functions (LFs). The observed LFs are corrected for field star contamination determined with the help of galactic star count model.
Piskunov, A. E. +4 more
openaire +2 more sources
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
The Luminosity Function and Density Distribution of Disk Population Stars [PDF]
The Astronomical Journal, 1972 The density distribution and luminosity function of the disk population are investigated, using star counts as a function of V and B-V for several thousand stars near the North Galactic Pole. Having estimated the contributions to the counts due to Population II stars and disk giants and subgiants, the remaining stars are assumed to constitute a pure ...
openaire +2 more sources
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source