Results 31 to 40 of about 906,285 (242)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

PARSEC evolutionary tracks of massive stars up to 350 M ☉ at metallicities 0.0001 ≤ Z ≤ 0.04 [PDF]

, 2015
We complement the PARSEC data base of stellar evolutionary tracks with new models of massive stars, from the pre-main sequence phase to the central carbon ignition. We consider a broad range of metallicities, 0.0001$\leq Z \leq$0.04 and initial masses up
Yang Chen, A. Bressan, L. Girardi, P. Marigo, X. Kong, A. Lanza   +5 more
semanticscholar   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

The IACOB project: III. New observational clues to understand macroturbulent broadening in massive O- and B-type stars ? [PDF]

, 2016
Context. The term macroturbulent broadening is commonly used to refer to a certain type of non-rotational broadening affecting the spectral line profiles of O- and B-type stars.
S. Simón-Díaz, S. Simón-Díaz, M. Godart, M. Godart, M. Godart, N. Castro, A. Herrero, A. Herrero, C. Aerts, C. Aerts, J. Puls, J. Telting, L. Grassitelli   +12 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Evidence of magnetic field decay in massive main-sequence stars [PDF]

, 2016
A significant fraction of massive main-sequence stars show strong, large-scale magnetic fields. The origin of these fields, their lifetimes, and their role in shaping the characteristics and evolution of massive stars are currently not well understood ...
L. Fossati, F. Schneider, N. Castro, N. Langer, S. Simón-Díaz, Aline Muller, A. D. Koter, T. Morel, V. Petit, H. Sana, G. Wade   +10 more
semanticscholar   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

A high fraction of Be stars in young massive clusters: evidence for a large population of near-critically rotating stars [PDF]

, 2016
Recent photometric analysis of the colour-magnitude diagrams (CMDs) of young massive clusters (YMCs) have found evidence for splitting in the main sequence and extended main sequence turn-offs, both of which have been suggested to be caused by stellar ...
N. Bastian, I. Cabrera-Ziri, I. Cabrera-Ziri, F. Niederhofer, S. D. Mink, C. Georgy, D. Baade, M. Correnti, C. Usher, M. Romaniello   +9 more
semanticscholar   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source