Results 111 to 120 of about 397,713 (267)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stochastic analysis of compact stars under composite polytropes. [PDF]

Sci Rep
Nouh MI, El-Essawy SH, Foda MM, Aboueisha MS.   +3 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Patterns and Clinical Efficacy of Biologics Switching in Patients With Severe Asthma: A Systematic Review and Meta-Analysis. [PDF]

Allergy
Zheng Y, Li YC, Li SJ, Xu M, Hu JQ, Tian WQ, Chen SW, Li XH, He Y, Lu G, Akdis M, Agache I, Akdis CA, Gao YD.   +13 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Codesign and knowledge translation of the Strength-based, Tiered, Accessible Resources and Supports (STARS) for Kids study to identify and support child development, parental mentalwell-being and family psychosocial needs: a mixed-methods research protocol. [PDF]

BMJ Paediatr Open
John JR, Robinson H, Lambiase S, Nicholls S, Diez M, Barr KR, Ostojic K, Doyle AK, Kliendienst L, Foster M, Syron L, Carson T, Kohlhoff J, Dadich A, Brennan C, Katsamangos B, Kemp L, Finlay-Jones A, O'Loughlin G, Boydell K, Raman S, Deen N, Lawson K, Schmied V, Katz I, Page A, Grace R, Kanaan AM, Young R, Brandtman E, Bratel L, Hodgins M, Lingam R, Lam-Cassettari C, Goldfeld S, Walker AK, Lin PI, Morton S, Silva D, Downs J, Woolfenden S, Eapen V, Ngarra Wakulda Aboriginal Community Consultation Group, STARS for Kids author group, Aboriginal Community Consultation Group.   +44 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Increasing Safety Plan Use and Reducing Suicidal Ideation Among Emerging Adults: A Pilot Randomized Trial of the STARS Intervention. [PDF]

Suicide Life Threat Behav
Brown LA, Tran JT, Gallop R, Webster JL, Wolfe JR, Kautz MM, Zhu Y, Arcomano A, Nathan JB, Mayinja L, O'Connor AA, Mowery D, Mandell DS, Brown GK, Oquendo MA, Bauermeister JA.   +15 more
europepmc   +1 more source

On the gravitational stability of a disk of stars

, 1964
A. Toomre
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source