Results 181 to 190 of about 455,638 (315)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Codesign and knowledge translation of the Strength-based, Tiered, Accessible Resources and Supports (STARS) for Kids study to identify and support child development, parental mentalwell-being and family psychosocial needs: a mixed-methods research protocol. [PDF]

BMJ Paediatr Open
John JR, Robinson H, Lambiase S, Nicholls S, Diez M, Barr KR, Ostojic K, Doyle AK, Kliendienst L, Foster M, Syron L, Carson T, Kohlhoff J, Dadich A, Brennan C, Katsamangos B, Kemp L, Finlay-Jones A, O'Loughlin G, Boydell K, Raman S, Deen N, Lawson K, Schmied V, Katz I, Page A, Grace R, Kanaan AM, Young R, Brandtman E, Bratel L, Hodgins M, Lingam R, Lam-Cassettari C, Goldfeld S, Walker AK, Lin PI, Morton S, Silva D, Downs J, Woolfenden S, Eapen V, Ngarra Wakulda Aboriginal Community Consultation Group, STARS for Kids author group, Aboriginal Community Consultation Group.   +44 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Lone black holes promise fresh insights into the fates of massive stars. [PDF]

Proc Natl Acad Sci U S A
Croswell K.
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Observations of Exocomets. [PDF]

Space Sci Rev
Korth J, Norazman A, Bendahan-West R, Kennedy G, Madurga Favieres C, Iglesias D, Shubina O, Xu S, Roth NX.   +8 more
europepmc   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Prevalence of Morton's toe:  a systematic review and meta-analysis. [PDF]

F1000Res
Habib ZMH, Al-Qaed AN, Yahya AA, Al-Balushi MA, Almarabheh A, Nasr El-Din WA, Potu BK.   +6 more
europepmc   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

When dermoscopy of a nodule on the hysterectomy scar reveals peritoneal carcinomatosis from high-grade serous tubal carcinoma. [PDF]

Oxf Med Case Reports
Benchekroun K, Ghaleb M, Gallouj S, Eljouari O.   +3 more
europepmc   +1 more source