Results 91 to 100 of about 16,735,230 (295)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Labour Market Performance and Start-Up Costs: OECD Evidence [PDF]

, 2003
This paper is intended to make a contribution to the empirical literature explaining the rise of unemployment since the 1970s in western economies by means of interactions between shocks and institutions. The contribution is twofold. First, the impact of a general feature of developed economies that has been surprisingly neglected in the literature is ...
openaire   +4 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Rapid Biocathode Start-Up with Mixed Methanogenic–Electroactive Inocula for Enhanced Bioelectrochemical Performance

Applied Sciences
This study explores the use of a pre-acclimated Geobacter-enriched inoculum as a novel strategy to accelerate the start-up of biocathodes. Unlike conventional inoculation with broad-spectrum communities, the proposed inoculum combines a long-term ...
Tamara Joglar, Andrea Crespo-Barreiro, Mercedes Jiménez-Rosado, Raúl Mateos   +3 more
doaj   +1 more source

An Integrated Start-Up Method for Pumped Storage Units Based on a Novel Artificial Sheep Algorithm

Energies, 2018
Pumped storage units (PSUs) are an important storage tool for power systems containing large-scale renewable energy, and the merit of rapid start-up enable PSUs to modulate and stabilize the power system.
Zanbin Wang, Chaoshun Li, Xinjie Lai, Nan Zhang, Yanhe Xu, Jinjiao Hou   +5 more
doaj   +1 more source

‘Start-Up Nation’: The Making and Performativity of an Empty Signifier

M@n@gement
The article sheds light on the process of fabrication of a polysemous, ambiguous, and mocking French entrepreneurial expression – the ‘start-up nation’ – construed as an empty signifier. The fabrication of such empty signifiers in the discourses of entrepreneurship and management, what creates them and what they create, remains little explored ...
Champenois, C., Saurier, D., Béliard, E.   +2 more
openaire   +5 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Setting Up a Business in the Netherlands [PDF]

Why does one person actually succeed in starting a business, while a second gives up, and a third is still trying? To answer this question, a longitudinal study was set up in which 330 nascent entrepreneurs (people setting up a business) were followed ...
Bosma, N., Gelderen, A.M. van, Thurik, A.R.   +2 more
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Valorant and the Platformization of Free-To-Play Games: Framing the Work of Content Creators as a Cultural Commodity [PDF]

, 2022
By studying the early development stages of the free-to-play game Valorant (Riot Games, 2020), this research draws connections between game studies and recent platformization research.
van der Molen, Kas
core