Results 61 to 70 of about 1,249,618 (293)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Starting device with a molecular energy store
Izvestiya MGTU MAMI, 2015 The article presents the classification of auxiliary power sources and starters, sets out the basic requirements for them. The authors revealed the possibilities and prospects for use of molecular energy storage as a part of starters. Described are the developed portable starting device PPU-14 and test results.
S. A Lebedev +2 more
openaire +1 more source
Design of a Quantum Source of High-Frequency Gravitational Waves (HFGW) and Test Methodology
, 2004 The generation of High-Frequency Gravitational Waves (HFGW) has been identified as the required breakthrough that will lead to new forms of space propulsion. Many techniques have been devised to generate HFGW, but most of them exhibit marginal efficiency,
Fontana, Giorgio
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Research of Mine-used 3.3 kV Static Var Compensator Based on SVG
Gong-kuang zidonghua, 2011 For problems of large voltage fluctuation, low power factor, large line loss, difficult starting of device and so on of power supply system in working face, the paper proposed a technical route of var compensation which takes SVG as a core, and ...
ZHAO Zeng-yu, MA Gang, ZHU Nai-peng
doaj
THEORETICAL RESEARCH ON THERMAL MODELING OF A HIGH POWER AUDIO DEVICE [PDF]
Fiabilitate şi Durabilitate, 2012 This paper aims at analyzing the mechanism of heat transfer and consequently a thermal analysis. Data obtained provides a starting point in choosing solutions constructrive, mechanical and electrichal dynamic audio device prototype .A comprehensive ...
Dr.Constantin D.Stanescu +2 more
doaj
East European Journal of Physics, 2019 To ensure the controllability and high noise immunity while measuring the characteristics of the accelerators of relativistic electron beams (REB) “TEMP”, and parameters of the processes in them, triggering devices with galvanic isolation of input and ...
Aleksey B. Batrakov +5 more
doaj +1 more source
Directed transport as a mechanism for protein folding in vivo
, 2009 We propose a model for protein folding in vivo based on a Brownian-ratchet mechanism in the multidimensional energy landscape space. The device is able to produce directed transport taking advantage of the assumed intrinsic asymmetric properties of the ...
Alberts B. +9 more
core +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source