Results 81 to 90 of about 2,464 (163)

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Startups’ open innovation journeys with large companies

Revista Galega de Economía, 2020
This study explores what drives startups to open their innovation to large companies. The methodology used is a multiple case study with 10 startups from the UK and Spain Firstly, this study provides an in-depth insight from motivations and benefits of ...
doaj  

Tri‐Functional Electrocatalysis for Zinc–Air Battery Coupled Water Splitting: A Catalyst‐Electrode‐Device‐System Perspective

Advanced Science, EarlyView.
This review establishes a catalyst–electrode–device–system framework for tri‐functional HER/OER/ORR electrocatalysis that couples water splitting with Zn–air batteries. Five catalyst families are covered: noble‐metal, metal‐based, single‐atom, heterostructure, and metal‐free systems.
Xixi Di, Chao Duan, Shuzhen Li, Yiyang Che, Xiaoshuang Liu, Chuanyin Xiong, Mengxia Shen, Yichao Wang, Derek Hao, Yonghao Ni   +9 more
wiley   +1 more source

Dual Repression by IPA1 Fine‐Tunes OsbZIP79‐Mediated Salt Tolerance in Rice

Advanced Science, EarlyView.
Dual repression by IPA1 fine‐tunes OsbZIP79‐mediated salt tolerance in rice: direct transcriptional inhibition under normal conditions and salt‐induced degradation under stress. This dual mechanism activates OsbZIP79 to regulate Na+/K+ homeostasis and redox balance via downstream genes, enabling optimal salt stress response.
Hui Wang, Bo Liu, Can Hu, Chenfan Zheng, Yuting Wei, Xier Xu, Wei Yang, Yu Fang, Guangle Shen, Pedro García‐Caparros, Conghe Zhang, Qingyao Shu, Meng Jiang   +12 more
wiley   +1 more source

Smartphone‐Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release

Advanced Science, EarlyView.
A light‐activated catheter insert combines antimicrobial blue light with nitric oxide release to generate complementary oxidative and nitrosative stress, producing potent broad‐spectrum antimicrobial activity. The approach achieves greater than 4‐log reductions in bacterial and fungal viability and significantly reduces Staphylococcus aureus ...
Alexander Bruckmann, Adam Brooks Goodman, Myddelton C. Parker, Mark Garren, Ji Eun Park, Chad Schmiedt, Hitesh Handa, Elizabeth J. Brisbois   +7 more
wiley   +1 more source

Continuous Molecular Monitoring Using Electrochemical Aptamer‐Based Sensors: Remaining Challenges for Long‐Term In Vivo Deployment

Advanced Science, EarlyView.
Continuous molecular monitoring using electrochemical aptamer‐based sensors enables real‐time tracking of dynamic biomarkers with transformative potential for precision medicine. Achieving clinically relevant month‐long stability remains a central challenge due to multiple degradation pathways.
Shibo Liu, Xiangling Li, Wei Ouyang
wiley   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Artificial intelligence in education startups - Case study of some education startups in Algeria

مجلة العلوم و آفاق المعارف
This study aims to identify the extent of the use of artificial intelligence technology in education startups, by presenting the experiences and case studies of some Algerian startups in the field of education.
Bilal MECHAALI
doaj   +1 more source

Non‐Coding Transcripts From Diversified Members of IgLec Family Protect Antiviral Effectors From Viral miRNA

Advanced Science, EarlyView.
The IgLec gene family generates both protein‐coding antiviral effectors and non‐coding transcripts. Upon viral infection, non‐coding transcripts are preferentially targeted by viral miR‐N48, thereby buffering protein‐coding isoforms from repression. Depletion of these decoy transcripts compromises antiviral defense, revealing a non‐coding RNA‐mediated ...
Ying Huang, Rui Shen, Xin Huang, Gu‐Qin Ji, Jiang‐Feng Lan, Qian Ren   +5 more
wiley   +1 more source

Robust, Breathable and Stretchable Liquid Metal Composite Nanofibre for Physiological Electrical Signal Monitoring

Advanced Science, EarlyView.
A conductive TPU/liquid‐metal nanofibrous film is fabricated via ultrasonic dispersion, electrospinning, and mold imprinting. The film is breathable, stretchable, deformation‐stable, and provides electromagnetic shielding. n‐Butanol encapsulation mitigates liquid‐metal surface tension and improves biocompatibility. Stable ECG, EOG, EEG, and EMG signals
Cong Huang, Zhenyu Chen, Zedong Jiang, Yuhao Jiang, Haohong Jiang, Zhenli Zhou, Yunlu Pan, Shu‐Jen Wang   +7 more
wiley   +1 more source