Results 111 to 120 of about 489,624 (298)
Isothermal elastohydrodynamic lubrication of point contacts. 4: Starvation results [PDF]
The influence of lubricant starvation on minimum film thickness was investigated by moving the inlet boundary closer to the contact center. The following expression was derived for the dimensionless inlet distance at the boundary between the fully ...
Dowson, D., Hamrock, B. J.
core +1 more source
Effects of starvation and refeeding on the hematological and serum parameters and body proximate composition of Caspian salmon (Salmo trutta caspius) fingerligs [PDF]
, 2016 This study was conducted to investigate the effects of periods of starvation and refeeding on some hematological, serum parameters and whole body proximate composition in Caspian salmon (Salmo trutta caspius).
Jani khalili, Kh. +3 more
core
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Advanced Science, EarlyView.This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu +7 more
wiley +1 more source
Advanced Science, EarlyView.The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang +7 more
wiley +1 more source
Control of Nucleotide Metabolism and Ribosomal Ribonucleic Acid Synthesis During Nitrogen Starvation of \u3cem\u3eEscherichia coli\u3c/em\u3e [PDF]
, 1972 Ribosomal ribonucleic acid (RNA) synthesis and ribonucleoside triphosphate metabolism were studied in cultures of Escherichia coli subjected to starvation for inorganic nitrogen.
Irr, Joseph D.
core +1 more source
Halofuginone is a Molecular Glue Degrader of Integrin β4
Advanced Science, EarlyView.Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong +8 more
wiley +1 more source
On the Fairness of Internet Congestion Control over WiFi with Deep Reinforcement Learning
Future InternetFor over forty years, TCP has been the main protocol for transporting data on the Internet. To improve congestion control algorithms (CCAs), delay bounding algorithms such as Vegas, FAST, BBR, PCC, and Copa have been developed.
Shyam Kumar Shrestha +2 more
doaj +1 more source
Galaxy Quenching from Cosmic Web Detachment
, 2019 We propose the Cosmic Web Detachment (CWD) model, a framework to interpret the star-formation history of galaxies in a cosmological context. The CWD model unifies several starvation mechanisms known to disrupt or stop star formation into one single ...
Aragon-Calvo, Miguel A. +2 more
core +3 more sources
A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes
Advanced Science, EarlyView.We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen +13 more
wiley +1 more source