Genomic Mutations of the STAT5 Transcription Factor Are Associated with Human Cancer and Immune Diseases. [PDF]
Int J Mol Sci, 2022 Signal transducer and activation of transcription 5 (STAT5) is a key transcription factor that regulates various biological processes in mammalian development. Aberrant regulation of STAT5 has also been causally linked to many diseases, including cancers
Kim U, Shin HY.
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Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells. [PDF]
J Biol Chem, 2017 The hormone prolactin (PRL) contributes to breast cancer pathogenesis through various signaling pathways, one of the most notable being the JAK2/signal transducer and activator of transcription 5 (STAT5) pathway.
Schauwecker SM +3 more
europepmc +5 more sources
The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation [PDF]
Nature Communications, 2019 The oncogene STAT5 is involved in cancer cell proliferation. Here, the authors use STAT5 protein to assemble its own small molecule inhibitors via Mannich ligation (three-component-reactions) and show that the resultant ligands can inhibit the ...
Ee Lin Wong +9 more
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How Intrinsic Molecular Dynamics Control Intramolecular Communication in Signal Transducers and Activators of Transcription Factor STAT5. [PDF]
PLoS ONE, 2015 Signal Transducer and Activator of Transcription STAT5 is a key mediator of cell proliferation, differentiation and survival. While STAT5 activity is tightly regulated in normal cells, its constitutive activation directly contributes to oncogenesis and ...
Florent Langenfeld +4 more
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The Effect of Shionone on Sepsis-Induced Acute Lung Injury by the ECM1/STAT5/NF-κB Pathway
Frontiers in Pharmacology, 2022 Purpose: The purpose of the present study was to estimate the effect of shionone (SHI) on sepsis-induced acute lung injury (ALI).Methods: The cecal ligation and puncture (CLP) surgery was performed to induce sepsis in mice.
Yi Song +10 more
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ELF5 modulates casein synthesis in goat mammary epithelial cells via JAK2/STAT5 signaling pathway [PDF]
Animal BioscienceObjective Goat milk contains a high concentration of caseins which are beneficial to human health. Understanding the regulatory mechanisms of casein synthesis in goats contribute to improving milk quality.
Yuzhu Guo +8 more
doaj +2 more sources
Hypoxia promotes progression of cervical cancer by modulating the ATXN3-enhanced P53 stability or STAT5 phosphorylation [PDF]
Cell Death DiscoveryThis study examines hypoxia’s role in regulating ATXN3 (ATXN3) across cervical cancer subtypes and its impact on tumor progression. We analyzed ATXN3 expression in clinical samples and cell lines (C33A, HeLa, SiHa), assessing proliferation/migration ...
Rong Zhang +8 more
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eLife, 2016 The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remain uncertain.
Alejandro Villarino +11 more
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Scientific Reports, 2017 The transcription factor STAT5b is a target for tumour therapy. We recently reported catechol bisphosphate and derivatives such as Stafib-1 as the first selective inhibitors of the STAT5b SH2 domain.
Nagarajan Elumalai +7 more
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Nucleic Acids Research, 2008 Loss of the maintenance of genetic material is a critical step leading to tumorigenesis. It was reported that overexpression of Aurora-A and the constitutive activation of the epidermal growth factor (EGF) receptor (EGFR) are implicated in chromosome ...
Liang-Yi Hung, Joseph T Tseng
exaly +2 more sources