Results 131 to 140 of about 643,807 (225)

Insights Into Macrophage Polarization and M1/M2 Balance in Diabetic Foot Ulcers

Journal of Diabetes, Volume 18, Issue 3, March 2026.
This graphical abstract illustrates pharmaceutical agents that modulate M1/M2 macrophage polarization in diabetic foot ulcers (DFUs). M1 macrophages (red) drive inflammation, whereas M2 macrophages (blue) promote tissue repair. In DFUs, persistent M1 predominance contributes to chronic non‐healing. Five key agents targeting this imbalance are depicted:
Jing Zhang, Hong Li, Yulin Dong, Zhuoyan Zhou, Yuhan Wang, Xia Chen, Yulan Cai   +6 more
wiley   +1 more source

The Immune Cell Atlas of “Longevity Molecular Tag”: Identification of Principal Immune Cell Subsets and Their Underlying Molecular Regulatory Mechanisms

Aging Cell, Volume 25, Issue 3, March 2026.
This study aims to develop an immune cell atlas of the “Longevity Molecular Tags” by employing the Scissor algorithm to identify key immune cell subsets associated with longevity phenotypes. Subsequently, the underlying immune molecular mechanisms contributing to the longevity‐associated immune cell subsets were investigated through differential gene ...
Zhiling Zhang, Huabin Su, Shihui Fu, Fansen Ji, Liuguan Liang, Wanlu Song, Caiyou Hu, Liuxiang Wei, Erping Long, Yang Lin, Xiaolin Ni   +10 more
wiley   +1 more source

T‐bet Fate Mapping Reveals Gestational Stage‐Specific Transcriptional Adaptation of Decidual NK Cells

American Journal of Reproductive Immunology, Volume 95, Issue 3, March 2026.
ABSTRACT Problem Natural killer (NK) cells are critical regulators of immune balance at the maternal–fetal interface. T‐bet (Tbx21) is a key transcription factor shaping NK cell effector functions, yet its role in decidual NK (dNK) cell adaptation across gestation remains unclear.
Mona A. Mohamed, Yan Li, Andrea K. Wegrzynowicz, Payton N. Lindner, Jessica Vazquez, Gladys E. Lopez, Aleksandar K. Stanic   +6 more
wiley   +1 more source

Selective Janus kinase inhibitors exhibit different effects in murine immune aplastic anemia

HemaSphere, Volume 10, Issue 3, March 2026.
Jibran Durrani, Xingmin Feng, Zhijie Wu, Shouguo Gao, Ash Lee Manley, Liangliang Wu, Joshua Glass, Bhavisha A. Patel, Jichun Chen, Neal S. Young, Emma M. Groarke   +10 more
wiley   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

The X Factor in Immunity: Sex Differences Shaped by the X Chromosome

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Katherine B. Radovanovic, Megan Wynalda, Montserrat C. Anguera   +2 more
wiley   +1 more source

How Does Biological Sex Impact Mucosal Bacterial Infection? Mucosal Defenses and Bacterial Detection

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Urinary tract infections possess substantial sex disparities in the incidence, immune response, and progression of infection. Some of these distinctions may be due to sexual dimorphism in mucosal barriers or sex differences in the initial immune response to infection.
Laura Ramirez Finn, Molly A. Ingersoll
wiley   +1 more source

JAK-STAT signaling: molecular mechanism and targeted treatment in dento-maxillofacial abnormalities. [PDF]

Int J Oral Sci
Huang Z, Cui Y, Zhang W, Shen J, Dai Q, Sun S, Jiang L.   +6 more
europepmc   +1 more source

Activation of Male Liver Chromatin Accessibility and STAT5-Dependent Gene Transcription by Plasma Growth Hormone Pulses

Endocrinology, 2017
J. Connerney, Dana Lau-Corona, A. Rampersaud, D. Waxman   +3 more
semanticscholar   +1 more source

<i>Ascaris lumbricoides</i> antigen exposure modulates T cell activation via regulation of IL-15Rα expression, STAT5 phosphorylation, and promotes differentiation of BCL6^low B cells. [PDF]

Front Immunol
Pushpamithran G, Appelgren D, Gilman RH, Blomgran R.   +3 more
europepmc   +1 more source