Results 11 to 20 of about 643,807 (225)

The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5. [PDF]

Journal of Clinical Investigation, 2020
IL-17-producing RORγt+ γδ T cells (γδT17 cells) are innate lymphocytes that participate in type 3 immune responses during infection and inflammation. Herein, we show that γδT17 cells rapidly proliferate within neonatal lymph nodes and gut, where, upon ...
D. Kadekar, Rasmus Agerholm, John Rizk, H. Neubauer, Tobias Suske, B. Maurer, Monica Torrellas Viñals, E. Comelli, A. Taibi, R. Moriggl, Vasileios Bekiaris   +10 more
semanticscholar   +4 more sources

The STAT5 transcription factor in B-cells of patients with chronic lymphocytic leukemia [PDF]

Biopolymers and Cell, 2019
A. S. Matvieieva, L. M. Kovalevska, T. S. Ivanivska © 2019 A. S. Matvieieva et al.; Published by the Institute of Molecular Biology and Genetics, NAS of Ukraine on behalf of Biopolymers and Cell. This is an Open Access article distributed under the terms
A. Matvieieva, L. Kovalevska, T. Ivanivska, E. Klein, E. Kashuba   +4 more
semanticscholar   +3 more sources

STAT5 is a key transcription factor for IL-3-mediated inhibition of RANKL-induced osteoclastogenesis

Scientific Reports, 2016
Among the diverse cytokines involved in osteoclast differentiation, interleukin (IL)-3 inhibits RANKL-induced osteoclastogenesis. However, the mechanism underlying IL-3-mediated inhibition of osteoclast differentiation is not fully understood.
Jongwon Lee, S. Seong, Jung Ha Kim, Kabsun Kim, In-Je Kim, Byung-chul Jeong, K. Nam, K. Kim, L. Hennighausen, Nacksung Kim   +9 more
semanticscholar   +4 more sources

Growth Hormone Promotes the Association of Transcription Factor STAT5 with the Growth Hormone Receptor* [PDF]

Journal of Biological Chemistry, 1996
Members of the cytokine/growth hormone (GH)/prolactin receptor superfamily transduce signals by association and activation of JAK tyrosine kinases. For GH receptor (GHR), both JAK2 and the GHR undergo tyrosine phosphorylation upon GH stimulation.
Bixiong C. Xu, Xinzhong Wang, C. Darus, J. Kopchick   +3 more
semanticscholar   +3 more sources

Regulation of the Interferon regulatory factor-8 (IRF-8) Tumor Suppressor Gene by the Signal Transducer and Activator of Transcription 5 (STAT5) Transcription Factor in Chronic Myeloid Leukemia* [PDF]

Journal of Biological Chemistry, 2014
Background: The IRF-8 tumor suppressor gene is down-regulated in chronic myeloid leukemia (CML). Results: The STAT5 transcription factor regulates IRF-8 expression in CML cells. Conclusion: In CML, oncogene-mediated activation of STAT5 is responsible for
J. Waight, Debarati Banik, E. Griffiths, M. Nemeth, S. Abrams   +4 more
semanticscholar   +3 more sources

Analysis of TGFβ1-Induced activin A gene expression in kidney mesangial cells [PDF]

Frontiers in Molecular Biosciences
IntroductionThe cytokine activin A is emerging as an important regulator of kidney fibrosis. Its expression, negligible in normal kidney, is significantly increased in various fibrotic kidney diseases.
Asfia Soomro, Ifeanyi Kennedy Nmecha, Jackie Trink, Renzhong Li, Joan C. Krepinsky   +4 more
doaj   +2 more sources

Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function. [PDF]

Immunity, 2012
Cytokine-activated STAT proteins dimerize and bind to high-affinity motifs, and N-terminal domain-mediated oligomerization of dimers allows tetramer formation and binding to low-affinity tandem motifs, but the functions of dimers versus tetramers are unknown.
Jian-Xin Lin, Peng Li, Delong Liu, H. Jin, Jianping He, Mohammed Ata Ur Rasheed, Yrina Rochman, Lu Wang, Kairong Cui, Chengyu Liu, B. Kelsall, R. Ahmed, W. Leonard   +12 more
semanticscholar   +3 more sources

Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells. [PDF]

Cancer Research, 2008
Abstract The molecular mechanisms underlying progression of prostate cancer to the hormone-independent state are poorly understood. Signal transducer and activator of transcription 5a and 5b (Stat5a/b) is critical for the viability of human prostate cancer cells.
Shyh-Han Tan, Ayush Dagvadorj, F. Shen, L. Gu, Zhi-yong Liao, Junaid Abdulghani, Ying Zhang, E. Gelmann, T. Zellweger, Z. Culig, T. Visakorpi, L. Bubendorf, R. Kirken, J. Karras, M. Nevalainen   +14 more
semanticscholar   +3 more sources

Interleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene expression in T lymphocytes. [PDF]

Proceedings of the National Academy of Sciences, 1995
Although prolactin and interleukin 2 (IL-2) can elicit distinct physiological responses, we have found that their signal pathways share a common signal transducer and activator of transcription, STAT5. STAT5 was originally identified as a mammary gland factor induced by prolactin in lactating breast cells.
K. C. Gilmour, R. Pine, N. Reich
semanticscholar   +3 more sources

Discovery of Chromone‐Based Inhibitors of the Transcription Factor STAT5

ChemBioChem, 2008
Judith M. Müller, Bianca Sperl, W. Reindl, Anke Kiessling, T. Berg   +4 more
semanticscholar   +4 more sources