Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium. [PDF]
Molecular Endocrinology, 2002 Transcription factor Stat5 (signal transducer and activator of transcription) is essential for PRL-induced terminal differentiation of mouse mammary epithelial cells during pregnancy and lactation and has been implicated in mammary tumorigenesis. A new and sensitive immunological method to detect active, tyrosine phosphorylated Stat5 in situ revealed ...
M. Nevalainen +4 more
semanticscholar +4 more sources
The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. [PDF]
Immunity, 2008 The development of distinct dendritic cell (DC) subsets is regulated by cytokines. The ligand for the FMS-like tyrosine kinase 3 receptor (Flt3L) is necessary for plasmacytoid DC (pDC) and conventional DC (cDC) maturation. The cytokine GM-CSF inhibits Flt3L-driven pDC production while promoting cDC growth.
Eiji Esashi +5 more
semanticscholar +3 more sources
Prolactin and interleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor. [PDF]
Endocrinology, 1995 The cell surface receptors for PRL and interleukin-2 (IL-2) are structurally distinct, but share regulatory tasks in T lymphocytes. They can stimulate proliferation and activate transcription of over-lapping sets of genes of T cells. PRL and IL-2 receptor activation are both linked to the Jak/Stat (signal transducer and activator of transcription ...
F. Gouilleux +5 more
semanticscholar +5 more sources
Virology, 2006 Although HIV-1 (HIV) replicates poorly in non-dividing CD4 lymphocytes, resting T cells contribute to the latent reservoir. The gammac-related cytokines reverse this block to HIV infection; however, the molecular mechanisms controlling this process are not understood.
N. Selliah +8 more
semanticscholar +3 more sources
Evidence for a protective role of the STAT5 transcription factor against oxidative stress in human leukemic pre-B cells [PDF]
Leukemia, 2012 STAT5 transcription factors are involved in normal B lymphocyte development and in leukemogenesis. We show that the inhibition of STAT5A expression or activity in the NALM6, 697 and Reh leukemic pre-B cell lines, results in a higher spontaneous apoptosis and an increased FAS-induced cell death.
E. Cholez +15 more
semanticscholar +6 more sources
Antigen-specific monoclonal antibodies isolated from B cells expressing constitutively active STAT5. [PDF]
PLoS ONE, 2011 BACKGROUND: Fully human monoclonal antibodies directed against specific pathogens have a high therapeutic potential, but are difficult to generate. METHODOLOGY/PRINCIPAL FINDINGS: Memory B cells were immortalized by expressing an inducible active mutant ...
Ferenc A Scheeren +4 more
doaj +1 more source
Coregulation of Genetic Programs by the Transcription Factors NFIB and STAT5 [PDF]
Molecular Endocrinology, 2014 Mammary-specific genetic programs are activated during pregnancy by the common transcription factor signal transducer and activator of transcription (STAT) 5. More than one third of these genes carry nuclear factor I/B (NFIB) binding motifs that coincide with STAT5 in vivo binding, suggesting functional synergy between these two transcription factors ...
Gertraud W, Robinson +9 more
openaire +2 more sources
Translational Oncology, 2022 Signal transducer and activator of transcription 5 (STAT5) signaling plays a pathogenic role in both hematologic malignancies and solid tumors. In acute myeloid leukemia (AML), internal tandem duplications of fms-like tyrosine kinase 3 (FLT3-ITD ...
Anna J. Dellomo +6 more
doaj +1 more source
Transcription Factor Stat5 Knockdown Enhances Androgen Receptor Degradation and Delays Castration-Resistant Prostate Cancer Progression In vivo [PDF]
Molecular Cancer Therapeutics, 2011 Abstract Signal transducer and activator of transcription 5 (Stat5) plays an important role in the transition of prostate cancer (PCa) to its castrate-resistant state. Pharmacologic targeting of Stat5 is a rational approach to delay castrate-resistant progression, in part, because Stat5 cooperates with the androgen receptor (AR) to ...
Christian Thomas +9 more
semanticscholar +3 more sources
Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells
Cell Reports, 2020 Summary: Natural killer (NK) cells are innate lymphocytes with the capacity to elicit adaptive features, including clonal expansion and immunological memory.
Gabriela M. Wiedemann +8 more
doaj +1 more source