Results 31 to 40 of about 643,807 (225)

The decoy oligodeoxynucleotide against HIF-1α and STAT5 ameliorates atopic dermatitis-like mouse model

Molecular Therapy: Nucleic Acids, 2023
Atopic dermatitis (AD) is a common inflammatory skin disease caused by an immune disorder. Mast cells are known to be activated and granulated to maintain an allergic reaction, including rhinitis, asthma, and AD. Although hypoxia-inducible factor-1 alpha
Mi-Gyeong Gwon, Jaechan Leem, Hyun-Jin An, Hyemin Gu, Seongjae Bae, Jong Hyun Kim, Kwan-Kyu Park   +6 more
doaj   +1 more source

A STAT5-Smad3 dyad regulates adipogenic plasticity of visceral adipose mesenchymal stromal cells during chronic inflammation

npj Regenerative Medicine, 2022
Adipogenic differentiation of visceral adipose tissue-resident multipotent mesenchymal stromal cells (VA-MSC) into adipocytes is metabolically protective.
Rahul Das, Jayeeta Giri, Pradyut K. Paul, Nicole Froelich, Raghavan Chinnadurai, Sara McCoy, Wade Bushman, Jacques Galipeau   +7 more
doaj   +1 more source

Evaluation of genome-wide chromatin library of Stat5 binding sites in human breast cancer

Molecular Cancer, 2005
Background There is considerable interest in identifying target genes and chromatin binding sites for transcription factors in a genome-wide manner. Such information may become useful in diagnosis and treatment of disease, drug target identification, and
Rui Hallgeir, Xie Jianwu, LeBaron Matthew J   +2 more
doaj   +1 more source

Ikaros antagonizes DNA binding by STAT5 in pre-B cells.

PLoS ONE, 2020
The IKZF1 gene, which encodes the Ikaros transcription factor, is frequently deleted or mutated in patients with B-cell precursor acute lymphoblastic leukemias that express oncogenes, like BCR-ABL, which activate the JAK-STAT5 pathway.
Beate Heizmann, Stéphanie Le Gras, Célestine Simand, Patricia Marchal, Susan Chan, Philippe Kastner   +5 more
doaj   +1 more source

The Inhibition of Stat5 by a Peptide Aptamer Ligand Specific for the DNA Binding Domain Prevents Target Gene Transactivation and the Growth of Breast and Prostate Tumor Cells

Pharmaceuticals, 2013
The signal transducer and activator of transcription Stat5 is transiently activated by growth factor and cytokine signals in normal cells, but its persistent activation has been observed in a wide range of human tumors.
Vida Vafaizadeh, Bernd Groner, Boris Brill, Natalia Delis, Richard Moriggl, Corina Borghouts, Christian Brendel, Axel Weber   +7 more
doaj   +1 more source

FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells.

PLoS ONE, 2014
Signal transducers and activators of transcription 5(STAT5) are cytokine induced signaling proteins, which regulate key immunological processes, such as tolerance induction, maintenance of homeostasis, and CD4 T-effector cell differentiation.
Aradhana Rani, Aradhana Rani, Roseanna Greenlaw, Manohursingh Runglall, Stipo Jurcevic, Susan John   +5 more
doaj   +1 more source

The natural chemopreventive agent sulforaphane inhibits STAT5 activity. [PDF]

PLoS ONE, 2014
Signal transducer and activator of transcription STAT5 is an essential mediator of cytokine, growth factor and hormone signaling. While its activity is tightly regulated in normal cells, its constitutive activation directly contributes to oncogenesis and
Sophia Pinz, Samy Unser, Anne Rascle
doaj   +1 more source

Altered Cytokine-Induced STAT3 and STAT5 Activation of Peripheral T Follicular Helper Cells Contributes to Vaccine-Non-Responsiveness in Aging and HIV. [PDF]

Aging Cell
Chronic immune activation and inflammation associated with aging and HIV skew Tfh signaling toward enhanced IL‐2–STAT5 activation, reinforcing IL‐2R expression through a positive feedback loop and suppressing Tfh helper differentiation programs, thereby contributing to impaired vaccine responsiveness.
Davis S, Kupritz J, Singh P, Pahwa S, Pallikkuth S.   +4 more
europepmc   +2 more sources

Astragalus polysaccharide ameliorates insulin resistance in HepG2 cells through activating the STAT5/IGF‐1 pathway

Immunity, Inflammation and Disease, 2023
Background Insulin resistance (IR) is considered as a major factor initiating type 2 diabetes mellitus and can lead to a reduction in glucose uptake that mainly occurs in the liver.
Xinxin Yue, Wei Hao, Min Wang, Yang Fu
doaj   +1 more source

Seasonal patterns of prolactin, prolactin receptor, and STAT5 expression in the ovaries of wild ground squirrels (Citellus dauricus Brandt)

European Journal of Histochemistry, 2023
Prolactin (PRL) is a hormone crucial for normal reproduction, functioning as an autocrine, paracrine, and endocrine factor. This study aimed to examine the immunolocalization and expression patterns of PRL, prolactin receptor (PRLR), and signal ...
Qingjing Gao, Wenqian Xie, Wenjing Lu, Yuning Liu, Haolin Zhang, Yingying Han, Qiang Weng   +6 more
doaj   +1 more source