Results 41 to 50 of about 643,807 (225)
Hepatology, EarlyView., 2022 Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo +14 more
wiley +1 more source
Dual-Specificity Phosphatase 4 Regulates STAT5 Protein Stability and Helper T Cell Polarization.
PLoS ONE, 2015 Immune responses are critically regulated by the functions of CD4 helper T cells. Based on their secreted cytokines, helper T cells are further categorized into different subsets like Treg or Th17 cells, which suppress or promote inflammatory responses ...
Wan-Yi Hsiao +4 more
doaj +1 more source
Stem Cell Reports, 2015 Intestinal epithelial stem cells (IESCs) control the intestinal homeostatic response to inflammation and regeneration. The underlying mechanisms are unclear. Cytokine-STAT5 signaling regulates intestinal epithelial homeostasis and responses to injury. We
Shila Gilbert +14 more
doaj +1 more source
Hepatic expression of glutamine synthetase in rats is controlled by STAT5 and TCF transcription factors† [PDF]
Hepatology, 2006 In mammalian liver, high glutamine synthetase (GS) expression is restricted to hepatocytes surrounding the terminal venules. The most important enhancer of the GS gene is located approximately 2520 base pairs (bp) upstream from the transcriptional start point. The nature of the transcription factors that bind to the enhancers has remained enigmatic. In
Max, Werth +2 more
openaire +2 more sources
Benzodiazepines Drive Alteration of Chromatin at the Integrated HIV-1 LTR
Viruses, 2020 Antiretroviral therapy (ART) lowers human immunodeficiency virus type 1 (HIV-1) viral load to undetectable levels, but does not eliminate the latent reservoir.
Weam Elbezanti +8 more
doaj +1 more source
Survival response of hippocampal neurons under low oxygen conditions induced by Hippophae rhamnoides is associated with JAK/STAT signaling. [PDF]
PLoS ONE, 2014 Janus activated kinase/signal transducers and activators of transcription (JAK/STATs) pathway are associated with various neuronal functions including cell survival and inflammation.
Manimaran Manickam, Rajkumar Tulsawani
doaj +1 more source
FEBS Letters, 1999 Salmon insulin‐like growth factor‐I (sIGF‐I) expression is, as in mammals, induced by growth hormone (GH). To elucidate the mechanism by which GH stimulates the transcription of the IGF‐I gene, we transiently transfected Hep3B cells expressing the rat GH receptor with a sIGF‐I promoter‐luciferase reporter construct.
Isidoro Metón +3 more
semanticscholar +4 more sources
Batf stabilizes Th17 cell development via impaired Stat5 recruitment of Ets1‐Runx1 complexes
EMBO Journal, 2023 Although the activator protein‐1 (AP‐1) factor Batf is required for Th17 cell development, its mechanisms of action to underpin the Th17 program are incompletely understood.
Duy Pham +5 more
semanticscholar +1 more source
Frontiers in Neurology, 2021 The HIV-1 pandemic is a significant challenge to the field of medicine. Despite advancements in antiretroviral (ART) development, 38 million people worldwide still live with this disease without a cure.
Angel Lin +10 more
doaj +1 more source
The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation
Nature Communications, 2019 The transcription factor Foxp3 and Stat5 modulate lineage stability and function of regulatory T (Treg) cells to promote immune homeostasis. Here the authors show that O-GlcNAcylation of Foxp3 and Stat5, mediated by O-GlcNAc transferase (OGT), is ...
Bing Liu +10 more
doaj +1 more source