Results 51 to 60 of about 643,807 (225)

Mechanisms of EGF Regulation of COX-2 Through the STAT5 Signaling Pathway 
in Human Lung Adenocarcinoma A549 Cells

Chinese Journal of Lung Cancer, 2013
Background and objective It has been proved that cyclooxygenase-2 (COX-2) is a key factor in lung cancer oncogenesis. COX-2 can be induced by a number of cytokines and growth factors and can be regulated by the JAK/STAT signaling pathway.
Jian CUI, Yubo YAN, Yanzhong XIN, Jiyao LI, Qing DONG, Guibin ZHAO, Jingquan HAN, Shouqiang CAO   +7 more
doaj   +1 more source

M-CSF and GM-CSF Regulation of STAT5 Activation and DNA Binding in Myeloid Cell Differentiation is Disrupted in Nonobese Diabetic Mice

Clinical and Developmental Immunology, 2008
Defects in macrophage colony-stimulating factor (M-CSF) signaling disrupt myeloid cell differentiation in nonobese diabetic (NOD) mice, blocking myeloid maturation into tolerogenic antigen-presenting cells (APCs).
B. Rumore-Maton, J. Elf, N. Belkin, B. Stutevoss, F. Seydel, E. Garrigan, S. A. Litherland   +6 more
doaj   +1 more source

Plasma growth hormone pulses induce male-biased pulsatile chromatin opening and epigenetic regulation in adult mouse liver

eLife, 2023
Sex differences in plasma growth hormone (GH) profiles, pulsatile in males and persistent in females, regulate sex differences in hepatic STAT5 activation linked to sex differences in gene expression and liver disease susceptibility, but little is ...
Andy Rampersaud, Jeannette Connerney, David J Waxman   +2 more
doaj   +1 more source

Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor

Cell Reports, 2019
SUMMARY Follicular regulatory T (TFR) cells are a specialized suppressive subset that controls the germinal center (GC) response and maintains humoral self-tolerance.
E. Shen, H. Rabe, Lin Luo, Lei Wang, Qin Wang, Jie Yin, Xueying Yang, Wenquan Liu, Jessica M. Sido, H. Nakagawa, Lin Ao, Hye-Jung Kim, H. Cantor, J. Leavenworth   +13 more
semanticscholar   +1 more source

Data from Transcription Factor Stat5 Synergizes with Androgen Receptor in Prostate Cancer Cells

, 2023
<div>Abstract<p>The molecular mechanisms underlying progression of prostate cancer to the hormone-independent state are poorly understood. Signal transducer and activator of transcription 5a and 5b (Stat5a/b) is critical for the viability of human prostate cancer cells. We have previously shown that Stat5a/b is constitutively active in high-
Marja T. Nevalainen, James Karras, Robert A. Kirken, Lukas Bubendorf, Tapio Visakorpi, Zoran Culig, Tobias Zellweger, Edward P. Gelmann, Ying Zhang, Junaid Abdulghani, Zhiyong Liao, Lei Gu, Feng Shen, Ayush Dagvadorj, Shyh-Han Tan   +14 more
openaire   +1 more source

Short Stat5-interacting peptide derived from phospholipase C-β3 inhibits hematopoietic cell proliferation and myeloid differentiation.

PLoS ONE, 2011
Constitutive activation of the transcription factor Stat5 in hematopoietic stem/progenitor cells leads to various hematopoietic malignancies including myeloproliferative neoplasm (MPN).
Hiroki Yasudo, Tomoaki Ando, Wenbin Xiao, Yuko Kawakami, Toshiaki Kawakami   +4 more
doaj   +1 more source

STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus

Nature Communications, 2020
BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets ...
Yongyao Fu, Jocelyn Wang, Gayathri Panangipalli, Benjamin J. Ulrich, Byunghee Koh, Chengxian Xu, Rakshin Kharwadkar, Xiaona Chu, Yue Wang, Hongyu Gao, Wenting Wu, Jie Sun, Robert S. Tepper, Baohua Zhou, Sarath Chandra Janga, Kai Yang, Mark H. Kaplan   +16 more
doaj   +1 more source

Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells. [PDF]

PLoS ONE, 2013
IL-2 is the primary growth factor for promoting survival and proliferation of activated T cells that occurs following engagement of the Janus Kinase (JAK)1-3/and Signal Transducer and Activator of Transcription (STAT) 5 signaling pathway.
Zsuzsanna S Nagy, Jeremy A Ross, Georgialina Rodriguez, Balint L Balint, Lajos Szeles, Laszlo Nagy, Robert A Kirken   +6 more
doaj   +1 more source

The Role of STAT5 in Tyrosine Kinase Inhibitor (IMATINIB) Resistance in CML Patients

Acta Medica Indonesiana, 2020
Chronic myeloid leukemia (CML) is a clonal haemopoietic stem cell disorders with reciprocal translocation in chromosome 9 (ch9) and 22 (ch22) which cause the fusion of Break cluster region-Abelson murine leukemia (BCR-ABL) oncogene.
Anastasia Putri, Ikhwan Rinaldi, Melva Louisa, Soekamto Koesnoe   +3 more
doaj   +2 more sources

Effect of all-trans retinoic acid on casein and fatty acid synthesis in MAC-T cells [PDF]

Asian-Australasian Journal of Animal Sciences, 2020
Objective Caseins and fatty acids of milk are synthesized and secreted by the epithelial cells of the mammary gland. All-trans retinoic acid (ATRA), an active metabolite of vitamin A, has been shown to promote mammary development.
Xian-Dong Liao, Chang-Hai Zhou, Jing Zhang, Jing-Lin Shen, Ya-Jing Wang, Yong-Cheng Jin, Sheng-Li Li   +6 more
doaj   +1 more source