Results 151 to 160 of about 2,190,945 (258)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

An Inverse Generalized Conversion Filter for State Estimation in Nonlinear Adversarial Sensing Systems. [PDF]

Sensors (Basel)
Xi YA, Dong XH, Wu SY.
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

State Inference in Variational Bayesian

, 2006
Nonlinear source separation can be performed by inferring the state of a nonlinear state-space model. We study and improve the inference algorithm in the variational Bayesian blind source separation model introduced by Valpola and Karhunen in 2002. As
Antti Honkela, Juha Karhunen, Matti Tornio, Tapani Raiko, Nonlinear State-Space Models   +4 more
core  

FreqMamba: Spatial-Frequency Fusion and State Space Sequence Modeling for Deepfake Detection. [PDF]

Sensors (Basel)
Li Z, Chen Y, Li M, Wang R, Liu H.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Kernel embeddings and the separation of measure phenomenon. [PDF]

Proc Natl Acad Sci U S A
Santoro LV, Waghmare KG, Panaretos VM.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Automatic time series forecasting: the forecast package for R. [PDF]

Automatic forecasts of large numbers of univariate time series are often needed in business and other contexts. We describe two automatic forecasting algorithms that have been implemented in the forecast package for R.
Rob J. Hyndman, Yeasmin Khandakar
core  

Learning stable radiation boundaries for wave simulations via passive neural state-space models. [PDF]

iScience
Li A, Wang X, Wang Y, Wang S.
europepmc   +1 more source