Results 91 to 100 of about 711,827 (305)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Национальный психологический журналRelevance. Cognitive functions are professionally important qualities, which are an essential part of professional requirements to specialists of extreme profile. Firefighters have to remember building plans of protected objects and their characteristics,
Ekaterina V. Marchenko, Alyona D. Issar
doaj +1 more source
State Aid to the Romanian Steel and Coal Sectors: Issues Related to Accession [PDF]
Romanian Journal of European Affairs, 2004 This article aims to offer to the non-specialist reader a concise introduction to the main elements of the state aid acquis, and inform on what lies ahead of Romania in the accession process in relation to state aid control, based on the precedent of the
Isabela Atanasiu, Gheorghe Oprescu
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Национальный психологический журналBackground. Despite the development of technologies, the question of effective tools for training memory and attention remains open. Research is being conducted on training various cognitive processes but it is insufficient. For cadets of the Emergency
Ekaterina V. Marchenko , Alyona D. Issar
doaj +1 more source
Evaluation of the effectiveness of state aid offered to enterprises during the COVID-19 pandemic. [PDF]
Procedia Comput Sci, 2021 Łopatka A, Fedorowicz K.
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Теоретическая и экспериментальная психологияBackground. Maintaining mental health and psychological well-being of the specialists of EMERCOM of Russia requires, along with implementation of measures for the rapid restoration of their working capacity, also the development of their self-regulation ...
Julia S. Shoigu, Anastasia А. Tarasova
doaj +1 more source
Vertical industrial policy in the EU: an empirical analysis of the effectiveness of state aid [PDF]
This paper assesses the effectiveness of vertical industrial policies within the European Union. Vertical industrial policy is defined as government support of specific firms or industries ("picking winners" or "supporting losers").
Jodar, Sandra, Gual, Jordi
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source