Results 31 to 40 of about 1,244,483 (233)

A política e as bases do direito educacional

Cadernos Cedes
Este ensaio alude à relação entre sociedade, Estado e direito, tendo como elemento mediador a educação. Inicialmente, faz-se a exposição dos momentos distintos e marcantes da política social no século XX no Brasil: o primeiro período: a política social ...
EVALDO VIEIRA
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Política, Educación y Territorio en Chile (1950 - 2010): De las acciones colectivas a las acciones del mercado Política, Educação e Território no Chile (1950 - 2010): Das ações coletivas às ações do mercado Policy, Education and Territory in Chile (1950 - 2010): From Collective Action to Market Action

Educación y Educadores, 2012
Este artículo describe el trayecto de la política educativa territorial en Chile desde un enfoque sustentado en el Estado de Compromiso -anterior a la Dictadura- a un Estado Subsidiario que permanece inalterable en esta época.
Moyra Marcela Castro-Paredes
doaj  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Education, reconstruction and state building in Afghanistan [PDF]

Forced Migration Review, 2006
Since the December 2001 Bonn Agreement, Afghanistan has adopted a new constitution, held democratic elections and established a nationalarmy. Education, however, has been treated as merelyan ‘add on’ to the process of nation building.
Jeaniene Spink
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Nipah virus: a summary for clinicians

International Journal of Emergency Medicine
Objectives This article is one of a series on acute, severe diseases of humans caused by emerging viruses for which there are limited or no licensed medical countermeasures.
Corri B. Levine, Lauren M. Sauer, Susan L. F. McLellan, Jared D. Evans, On behalf of the State of the Science Working Group of the National Ebola Training and Education Center’s (NETEC’s) Special Pathogens Research Network (SPRN)   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

O legado educacional do regime militar

Cadernos Cedes
Este texto se propõe a uma retomada da política educacional e das realizações da ditadura militar no Brasil, pondo em destaque aspectos que se fazem presentes, ainda hoje, na educação brasileira.
Dermeval Saviani
doaj   +1 more source