Results 71 to 80 of about 1,244,483 (233)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Formal education, health literacy and Mini-Mental State Examination
Dementia & NeuropsychologiaThe Mini-Mental State Examination (MMSE) is a widely used screening test for cognitive impairment, but is heavily biased by education. Educational level has frequently been ranked using years of schooling, which may not be a good indirect measure of ...
Sonia Maria Dozzi Brucki +3 more
doaj +1 more source
Reduced oblique effect in children with Autism Spectrum Disorders (ASD)
Frontiers in Neuroscience, 2016 People are very precise in the discrimination of a line orientation relative to the cardinal (verti-cal and horizontal) axes, while their orientation discrimination sensitivity along the oblique ax-es is less refined.
Olga V Sysoeva +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Is There a Correlation Between the Level of Education and Economic Growth in a State?
CECCAR Business ReviewEducation plays a crucial role in a country’s economic development. It can support economic progress by increasing and developing human capital, namely qualified and trained human resources.
Radu CIOBANU +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
[The North Rhine-Westphalia state programme "Education and Health NRW"-sustainable development and establishment of the good healthy school in the German state of North Rhine-Westphalia]. [PDF]
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 2022 Opitz M.
europepmc +1 more source
Education, state and citizenship [PDF]
Scandinavian Economic History Review, 2015 This nine-chapter (plus introduction) anthology comes out of the large research project The Nordic Welfare State – Historical Foundations and Future Challenges which started in 2007 and is based in...
openaire +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source