Results 141 to 150 of about 1,582,558 (310)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Division of Epidemiology and Surveillance Capacity Development 2005 annual report
The Division of Epidemiology and Surveillance Capacity Development (DESCD) 2005 Annual Report is the division\u2019s first annual report, one that reflects the many changes that DESCD and the Centers for Disease Control and Prevention\u2019s (CDC) global
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Business and PoliticsSince the 1980s, state capacity has been a major explanation for countries leaving the middle-income trap. However, this literature is unable to explain the failed experiences of countries with relatively high state capacity.
Sebastian Carrasco, Aldo Madariaga
doaj +1 more source
Early investments in state capacity promote persistently higher levels of social capital. [PDF]
Proc Natl Acad Sci U S A, 2020 Jensen JL, Ramey AJ.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
QoS Provisioning in Wi-Fi Networks: Capacity Modeling and Resource Control
, 2005 The ubiquitous Wireless Fidelity (Wi-Fi) networks, and their increasing quality of service (QoS) requirements for emerging applications, motivate extensive studies of QoS provisioning in such networks.
Hui, Jie
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Policymaking in a low-trust state: legitimacy, state capacity, and responses to COVID-19 in Hong Kong. [PDF]
Policy Soc, 2020 Hartley K, Jarvis DSL.
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Institutions Taking Root : Building State Capacity in Challenging Contexts
, 2014 Building and operating successful public institutions is a perennial and long-term challenge for governments, which is compounded by the volatile conditions found in fragile settings.
Vinuela, Lorena +2 more
core +1 more source
Revista Brasileira de Gestão e Desenvolvimento RegionalThis research aims to analyse the relationship between the state capacities of the municipalities of the Legal Amazon region and their municipal development. It used the factorial analysis technique, which indicated the intensity of the relationship between the variables and their factors, attributing weight to the analysed variables, and through the ...
Letícia Linhales da Silva +2 more
openaire +1 more source