Results 111 to 120 of about 3,141,228 (339)

The State of Computational Science in Fission and Fusion Energy

open access: yes
The tools used to engineer something are just as important as the thing that is actually being engineered. In fact, in many cases, the tools can indeed determine what is engineerable. In fusion and fission1 energy engineering, software has become the dominant tool for design. For that reason, in 2024, for the first time ever, we asked 103 computational
Coto, Andrea Morales, Verma, Aditi
openaire   +2 more sources

Computer Science in Transcaucasia and Baltic States: a Comparative Bibliometric Analysis

open access: yesMathematical Problems of Computer Science, 2019
Based on the Web of Science, InCites database, this article will analyze the publication output of the Transcaucasia and Baltic states in computer science research field, their citations, as well as international collaboration in the field of computer science. The obtained results demonstrate that publications on computer science from the Baltic states
Shushanik Sargsyan, Edita Gzoyan
openaire   +2 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Modern trends in knowledge representation and expert system technology

open access: yesLe Matematiche, 1988
We will not be concerned with hardware aspects but we will discuss the present state of methodological concepts and software tools. Our main examples stem from the research activities at the Computer Science Department of the University of Kaiserslautern.
Klaus Nökel, Michael M. Richter
doaj  

The staffing of science departments in New Zealand secondary schools : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Education at Massey University [PDF]

open access: yes, 1980
This thesis attempts to ascertain the state of staffing in science departments of New Zealand Secondary Schools as at 1st September 1980. This study updates, and extends, the work done by E.J. Searle (1954) and O.
Gerritsen, Max Anthony
core  

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

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