Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan+10 more
wiley +1 more source
Autonomous adaptive optimization of NMR experimental conditions for precise inference of minor conformational states of proteins based on chemical exchange saturation transfer. [PDF]
Kasai T, Kigawa T.
europepmc +1 more source
Common Metrics: Lessons from Building a Collaborative Process for the Examination of State-level K–12 Computer Science Education Data [PDF]
Rebecca Zarch+5 more
openalex +1 more source
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim+8 more
wiley +1 more source
Correction: Rashid et al. A Minority Class Balanced Approach Using the DCNN-LSTM Method to Detect Human Wrist Fracture. <i>Life</i> 2023, <i>13</i>, 133. [PDF]
Rashid T+5 more
europepmc +1 more source
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka+10 more
wiley +1 more source
Editorial: Advances in computer vision: from deep learning models to practical applications. [PDF]
Zhu H, Yao R, Tang L.
europepmc +1 more source
Current State and Evolution of Russians Publication for Computer Science Flow
A. V. Glushanovskiy, Svetlana Vlasova
openalex +1 more source
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu+15 more
wiley +1 more source
Generative adversarial DacFormer network for MRI brain tumor segmentation. [PDF]
Zhang M+5 more
europepmc +1 more source