Results 81 to 90 of about 432,276 (266)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
A new cross-platform architecture for epi-info software suite
BMC Bioinformatics, 2018 Background The Epi-Info software suite, built and maintained by the Centers for Disease Control and Prevention (CDC), is widely used by epidemiologists and public health researchers to collect and analyze public health data, especially in the event of ...
Blake Camp +6 more
doaj +1 more source
The State of Computational Science in Fission and Fusion Energy
The tools used to engineer something are just as important as the thing that is actually being engineered. In fact, in many cases, the tools can indeed determine what is engineerable. In fusion and fission1 energy engineering, software has become the dominant tool for design. For that reason, in 2024, for the first time ever, we asked 103 computational
Coto, Andrea Morales, Verma, Aditi
openaire +2 more sources
Computer Science in Transcaucasia and Baltic States: a Comparative Bibliometric Analysis
Mathematical Problems of Computer Science, 2019 Based on the Web of Science, InCites database, this article will analyze the publication output of the Transcaucasia and Baltic states in computer science research field, their citations, as well as international collaboration in the field of computer science. The obtained results demonstrate that publications on computer science from the Baltic states
Shushanik Sargsyan, Edita Gzoyan
openaire +2 more sources
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Modern trends in knowledge representation and expert system technology
Le Matematiche, 1988 We will not be concerned with hardware aspects but we will discuss the present state of methodological concepts and software tools. Our main examples stem from the research activities at the Computer Science Department of the University of Kaiserslautern.
Klaus Nökel, Michael M. Richter
doaj
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source