Results 31 to 40 of about 2,116,675 (304)

Sustainability of centralized contract farming among tobacco smallholder farmers in Makoni North District, Zimbabwe

Cogent Social Sciences, 2021
The study explores centralized contract farming sustainability among tobacco smallholder farmers in Zimbabwe. Despite studies on centralized contract farming to date, little has been theorized with regard to its sustainability.
Bernard Chazovachii, Cashave Mawere, Leonard Chitongo   +2 more
doaj   +1 more source

The Legitimacy of the Contracting State [PDF]

, 2013
Globalization challenges our understanding of the state as the main source of legitimate law. This article will take this claim one step further. Today, we may also see the decline of the state, in its modern sense, from within. Evidence for this may be
Abegg, Andreas
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

ADMINISTRATIVE CONTRACTS IN COMPARATIVE LAW

Iustinianus Primus Law Review, 2022
Administrative contracts, as a type of contract concluded by the state, not for the purpose of performing its primary functions, but for the purpose of achieving generally useful goals, both for the society and the state, travel a long way from their ...
Natalija Darkovska
doaj  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

New Optimal-Control-Based Advertising Strategies and Coordination of a Supply Chain With Differentiated Products Under Consignment Contract

IEEE Access, 2019
With the aid of optimal control theory, the cooperative advertising problem is discussed for a supply chain under consignment contract in a competitive environment.
Zhihui Wu, Dongyan Chen
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The combination of the mandatory and dispositive principles in the legal regulation of contractual relations using the example of a contract for the supply of goods for state and municipal needs

Jus Strictum
The paper considers theoretical and practical aspects of legal regulation of the contract of supply for state and municipal needs by studying the interaction of dispositive and mandatory rules governing social relations formalized within the contract of ...
Elena V. Chuklova, Vladimir N. Trifonov
doaj   +1 more source