Results 191 to 200 of about 33,846,845 (391)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The impact of the Maritime Labor Convention on seafarers' working and living conditions: an analysis of port state control statistics. [PDF]

BMC Public Health, 2020
Fotteler ML, Andrioti Bygvraa D, Jensen OC.   +2 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Mutual Information State Intrinsic Control [PDF]

, 2021
Rui Zhao, Yang Gao, Pieter Abbeel, Volker Tresp, Wei Xu   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A parabrachial hub for need-state control of enduring pain. [PDF]

Nature
Goldstein N, Maes A, Allen HN, Nelson TS, Kruger KA, Kindel M, Yeung ATM, Smith NK, Carty JRE, Boccia L, Blank N, Lo E, Villari RE, Cho E, Marble EL, Awh M, Dumiaty Y, Chee MJ, Khanna R, Thaiss CA, Taylor BK, Kennedy A, Betley JN.   +22 more
europepmc   +1 more source

Mining ship deficiency correlations from historical port state control (PSC) inspection data. [PDF]

PLoS One, 2020
Fu J, Chen X, Wu S, Shi C, Wu H, Zhao J, Xiong P.   +6 more
europepmc   +1 more source

LPV Gain-Scheduled Observer-Based State Feedback for Active Control of Harmonic Disturbances with Time-Varying Frequencies

, 2012
Wiebke Heins, Pablo Ballesteros, Xinyu Shu, Christian Boh   +3 more
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Chiral edge state control of thermoelectric effects. [PDF]

Sci Adv
Huynh W, Liu B, Munyan S, Ahadi S, Stemmer S.   +4 more
europepmc   +1 more source