Results 301 to 310 of about 33,846,845 (391)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Investigation of a viable but non-culturable state in Porphyromonas gingivalis and host cell invasion. [PDF]

PLoS One
Oludiran A, Lewis B, Pudwill C, Chukkapalli S, Ahmadi H, Bannova D, Linares A, Burks J, Hillman JD, Dunn WA, Progulske-Fox A.   +10 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

An efficient remote driving shift control method of unmanned heavy tracked vehicles based on manned data mining. [PDF]

Sci Rep
Jia W, Zhao Y, Zheng H, Hu P, Gao Y.
europepmc   +1 more source

Fuzzy logic based nonlinear blending hybrid control of a kestrel-inspired ornithopter operating in sinusoidal and dryden gusts. [PDF]

Sci Rep
Abbasi SH, Saudagar AKJ, Nouman A, Hennache ML.   +3 more
europepmc   +1 more source

Optimized super-twisting active disturbance rejection control based on nonlinear extended state observer for aircraft attitude stabilization. [PDF]

Sci Rep
Yazdiniya F, Ansarifar G.
europepmc   +1 more source

An adaptive model predictive control approach for robust load frequency control under renewable energy disturbances. [PDF]

Sci Rep
Ayman M, Attia MA, Asim AM.
europepmc   +1 more source