Results 41 to 50 of about 4,095,936 (316)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

EFFICIENCY AUDIT OF USAGE BUDGETARY MEANS AS A PERSPECTIVE FORM OF IMPLEMENTATION OF STATE FINANCIAL CONTROL

open access: yesВестник Северо-Кавказского федерального университета, 2022
The article proves the necessity of financial control on the state authorities’ level of legislation observance on the use of budgetary funds. It reveals the peculiarities of financial control held by the Accounting Chamber of Russia.
Svetlana N. Borovyak   +3 more
doaj  

Does state control affect managerial incentives? Evidence from china's publicly listed firms

open access: yesJournal of Business Economics and Management, 2009
Using data for 1203 publicly listed firms in China during 1999–2002, this paper empirically investigates whether and to what extent state control affects managerial incentives, including managerial compensation and CEO turnover.
Chen Lin, Dongwei Su
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Illegal Online Gambling in Indonesia: Assessing State Securitization and Its Effectiveness

open access: yesJurnal Hubungan Internasional
After the COVID-19 pandemic, Southeast Asia has become a lucrative epicenter of illegal online gambling across borders. Illegal online gambling has emerged as a threat that harms the national interests of Southeast Asian nations.
Aswin Ariyanto Azis, M. Irfan Azhari
doaj   +1 more source

Problems ofrealization right tofreedom of speech in information internet-sources

open access: yesПроблеми Законності, 2018
The article is considered meaning of grounds and realization freedom of speech inthe Internet. The author studies issue of guarantees of the right to freedom of expression in online-information sources in the context of democratic state.
Тетяна Миколаївна Слінько   +1 more
doaj   +1 more source

State Auditor's report for the Fiscal Year ended June 30, 2022 [PDF]

open access: yes, 2022
The Office of State Auditor audited the financial statements of the South Carolina Office of the Governor, Executive Control of State using agreed upon ...
South Carolina State Auditor   +1 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Respect for the Scientific Community as a Prerequisite to Confidence in Institute of Science in Modern Russia

open access: yesСоциологическая наука и социальная практика, 2017
This article presents the dynamics of respect for the scientific community and confidence in Institute of Science in Russia. Respect and confidence are analyzed as temporal characteristics of social relationships.
Natalia N. Zarubina
doaj   +1 more source

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