Results 41 to 50 of about 340,114 (262)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

State Ownership and Corporate Innovation Efficiency

SSRN Electronic Journal, 2016
Abstract In this paper, we investigate the innovative efficiency of SOEs in China. Innovative efficiency refers to output of patents per dollar spending of R&D expenditure. The data indicate that minority SOEs are substantially more innovatively efficient than non-SOEs and majority SOEs.
CAO, Jerry X., CUMMING, Douglas J., ZHOU, Sili, ZHOU, Lu   +3 more
openaire   +3 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

INTELLECTUAL RENASCENCE GOES FROM BELOW (AND PULL FOR ITSELF THE ECONOMY [PDF]

Экономика региона, 2007
The difinition of municipal territory as some new formation is given in the article, its definition as "social corporate" structure is brought, its analogy with holding and mini-state is given. The aim, structure, and components of social corporation are
V.L. Makarov
doaj  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

A Liberalism in the Balance. John K. Galbraith between Technostructure and Countervailing Power

Scienza & Politica
The 1960s and 1970s constituted a fundamental turning point in US democracy marked by the apogee of liberalism and its crisis. In this context, one of the best known American economists, John Kenneth Galbraith, observes how technology, its constant ...
Roberta Ferrari
doaj   +1 more source

Infrastructure Debt Funds as a Source of Financing Smart City Projects: A Case Study of Kalyan Dombivali Municipal Corporation, Maharashtra [PDF]

Applied Research in Administrative Sciences, 2021
Every municipal corporation must prove continuous quality infrastructural services to people within its jurisdiction. But due to rise in population and paucity of financial resources, the Kalyan Dombivali Municipal corporation is not able to provide ...
RODE Sanjay
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Hegemony of Microsoft®: An Australian Story

Prometheus, 2003
Each Australian state and the Australian Capital Territory has signed a 'whole of education department' contract with the Microsoft® Corporation for the provision of operating systems and other software.
Kathryn Moyle
doaj   +1 more source