Results 41 to 50 of about 1,943,186 (295)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Target region extraction and segmentation algorithm for reflective tomography Lidar image
IET Image Processing, 2023 Reflective tomography Lidar is long‐range, high‐resolution imaging Lidar. Because the angular resolution is independent of detection range, it enjoys promising application prospects in imaging of small space targets, estimation of barycentre range of ...
Xinyuan Zhang +6 more
doaj +1 more source
Society, 2021 The urgency of the COVID-19 pandemic in Indonesia continues to increase. Companies in Indonesia are now focusing on CSR programs to assist the government in accelerating the handling of COVID-19.
Yani Hendrayani +1 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Photonics, 2023 A widely tunable 4.16–7.31 μm high-resolution mid-infrared optical parametric oscillator with a type-I BaGa4Se7 (BGSe) crystal pumped by a 1064 nm laser was demonstrated for the first time.
Xinqiang Zhao +8 more
doaj +1 more source
The Current State of the Insanity Defense in Virginia [PDF]
, 2015 Based upon British common law and legal precedents, the American legal system allows individuals with severe mental instability to plead not guilty by reason of insanity when charged with a criminal offense.
Gordon, Jacob
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Preparation and Chemical Protective Clothing Application of PVDF Based Sodium Sulfonate Membrane
Membranes, 2020 Chemical protective clothing (CPC) is major equipment to protect human skin from hazardous chemical warfare agents (CWAs), especially nerve agents and blister agents. CPC performance is mainly dominated by the chemical protective material, which needs to
Yue Zhao +10 more
doaj +1 more source
Surface Modification of ETFE Membrane and PTFE Membrane by Atmospheric DBD Plasma
Membranes, 2022 Fluorine resin membranes with excellent chemical resistance have great potential for the application of high-performance chemical protective clothing. However, it is difficult to integrate fluorine resins into other materials such as fabrics due to their
Zuohui Ji +4 more
doaj +1 more source