Results 131 to 140 of about 15,076,620 (365)
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
The Morphology of State Medicine in Great Britain [PDF]
, 1932 Harley Williams
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Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source
Medical applications of diamond magnetometry: commercial viability
, 2017 The sensing of magnetic fields has important applications in medicine, particularly to the sensing of signals in the heart and brain. The fields associated with biomagnetism are exceptionally weak, being many orders of magnitude smaller than the Earth's ...
Dale, Matthew W., Morley, Gavin W.
core
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
AMERICAN VERSUS EUROPEAN MEDICAL EDUCATION.A COMPARISON OF AMERICAN MEDICAL COLLEGE WORK WITH THAT OF EUROPEAN MEDICAL SCHOOLS. INCLUDING SOME THOUGHTS UPON FREE TRADE IN MEDICAL DIPLOMAS OF FOREIGN MANUFACTURE. Read in the Section of State Medicine at the Forty-first Annual Meeting of the American Medical Association, held at Nashville, Tenn., May, 1890. [PDF]
, 1890 Samuel O. L. Potter
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The ineffectiveness of state as a controller and owner [PDF]
The global market is largely a game without rules and without an arbitrator able to dispense necessary medicine. Undoubtedly, the crisis has caused the emergence of new challenges, which require the active role of the state in various areas.
Bojańczyk, Mirosław
core +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
WHAT SHOULD BE THE ATTITUDE OF THE STATE TOWARD THE PRACTICE OF MEDICINE? [PDF]
, 1911 Matthew L. Harris
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Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source