Results 221 to 230 of about 22,340,520 (273)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Symptom Terminology Normalization in Traditional Chinese Medicine: Development and Evaluation of a 2-Stage Deep Learning Framework Based on Fine-Grained Semantic Classification. [PDF]

JMIR Med Inform
Yao J, Gou X, Lai W, Gao Y, Wang S, Zhou C, Ye H, Tian J, Yi J, Cao D.   +9 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Suspected Acute Stanford Type A Aortic Dissection: A Case Report. [PDF]

Int Med Case Rep J
Chukwuocha CU, Okema JN, Uche CN, Ekengwu CC, Eghe JE, Ebunoluwa EO, Acomo G, Obal R, Pitua I, Bongomin F.   +9 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Retraction Note: MGMT Inhibition Restores ERα Functional Sensitivity to Antiestrogen Therapy. [PDF]

Mol Med
Bobustuc GC, Smith JS, Maddipatla S, Jeudy S, Limaye A, Isley B, Caparas MM, Constantino SM, Shah N, Baker CH, Srivenugopal KS, Baidas S, Konduri SD.   +12 more
europepmc   +1 more source

Correction: METTL3 facilitates tumor progression via an m⁶A-IGF2BP2-dependent mechanism in colorectal carcinoma. [PDF]

Mol Cancer
Li T, Hu PS, Zuo Z, Lin JF, Li X, Wu QN, Chen ZH, Zeng ZL, Wang F, Zheng J, Chen D, Li B, Kang TB, Xie D, Lin D, Ju HQ, Xu RH.   +16 more
europepmc   +1 more source

Few Caregivers of Older Adults With Dementia Have Shared Access to Their Care Recipients' Electronic Health Record Portal. [PDF]

J Am Geriatr Soc
Southerland LT, Walker DM, McAlearney AS, Wolff JL, Hebert CL.   +4 more
europepmc   +1 more source

The Association Between Loss of Consciousness and the Default Mode Network at the Chronic Stage of Diffuse Axonal Injury: A Diffusion Tensor Imaging Study. [PDF]

J Clin Med
Jang SH, Cho MJ, Byun DH.
europepmc   +1 more source