Results 51 to 60 of about 1,398,157 (281)

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and One‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

open access: yesArthritis Care &Research, Accepted Article.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti   +19 more
wiley   +1 more source

Aryl hydrocarbon receptor and Krüppel like factor 10 mediate a transcriptional axis modulating immune homeostasis in mosquitoes

open access: yesScientific Reports, 2022
Immune responses require delicate controls to maintain homeostasis while executing effective defense. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor.
Aditi Kulkarni   +6 more
doaj   +1 more source

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

open access: yesArthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner   +14 more
wiley   +1 more source

A Comprehensive Analysis on the Healthcare Systems in Latin America [PDF]

open access: yes, 2019
This comprehensive report summarizes and analyzes the current state of healthcare in Latin America, specifically in the countries of Mexico, Brazil, the Northern Triangle (El Salvador, Guatemala, and Honduras), the Andean Region (Ecuador, Peru, and ...
Calderon, Melinda   +5 more
core   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, Accepted Article.
Objectives Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies. To help patients and providers in the decision‐making process, we developed
Anahita Deboo   +19 more
wiley   +1 more source

Differential Item Functioning on the Patient Health Questionnaire‐8 by Disease Subtype, Language, Sex, and Age among People with Systemic Sclerosis: A Scleroderma Patient‐centered Intervention Network Cohort Study

open access: yesArthritis Care &Research, Accepted Article.
Objective Somatic items used in depression assessments can potentially overlap with symptoms related to physical illness, including systemic sclerosis (SSc). No studies have looked at whether somatic depression items may be influenced by diffuse versus limited SSc disease subtypes, which are associated with varying degrees of symptom presentation.
Sophie Hu   +109 more
wiley   +1 more source

Machado-Joseph Disease, A Case Report of Treatment Based on Phototherapy

open access: yesCaucasian Medical Journal
Machado-Joseph disease (MJD) is a rare autosomal dominant disease caused by a mutation in exon 10 of the ATXN3 gene resulting from a cytosine-adenine-guanine trinucleotide repeat. A case of a 48-year-old man with MJD is reported. His father, two paternal
Hugo Mendieta Zerón   +3 more
doaj   +1 more source

A meta-analysis on the effect of the feeding type and production system on the carcase quality of lambs

open access: yesItalian Journal of Animal Science, 2019
This meta-analysis aims to identify if there are differences between the weight of lamb carcases and their main characteristics according to the production systems and type of feeding around the word. Lambs finished on feeding supplement (with or without
Lizbeth Esmeralda Robles Jiménez   +5 more
doaj   +1 more source

AUTOIMMUNE POLYGLANDULAR SYNDROME PREVALENCE IN TOLUCA, MEXICO

open access: yesПаёми Сино, 2022
Objective: Autoimmune polyglandular syndromes (APS) are endocrinopathies whose main characteristic is the loss of immune tolerance. The objective of this work was to report the APS prevalence in an Internal Medicine Service from Toluca, Mexico ...
CONCEPCIÓN CARRILLO LE   +4 more
doaj   +1 more source

Evidence: Admission of Mathematical Probability Statistics Held Erroneous for Want of Demonstration of Validity [PDF]

open access: yes, 1967
In State v. Sneed the New Mexico Supreme Court limited its disapproval of evidence of probability statistics to the particular facts presented but failed to articulate specific safeguards for subsequent use of such evidence. This note explores the nature

core   +1 more source

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