Results 101 to 110 of about 171,965,011 (299)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Governor Corzine's State of the State

, 2009
Governor Corzine discusses the economy and his administration's efforts, the coming year, education and public safety, and budget reductions in the current and upcoming budget in his State of the State ...
Office of the Governor, Corzine, Jon
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Results of long-term research of threatened insect species in selected regions of European Russia

Nature Conservation Research: Заповедная наука
Insects, as the most diverse group of invertebrates, are often unfairly underrepresented in Red Lists of threatened taxa. Despite the significant biodiversity and ecosystem functionality of this group, regional Red lists of taxa often ignore truly ...
Alexander B. Ruchin, Leonid V. Egorov
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

State of nature 2019 [PDF]

, 2019
State of Nature 2019 presents an overview of how the country’s wildlife is faring, looking back over nearly 50 years of monitoring to see how nature has changed in the UK, its Crown Dependencies and Overseas Territories.
Beckmann, B., Hawley, J., Harrower, C., Hughes, J., Dunn, E., Symes, N., Pescott, O.L., Boersch-Supan, P.H., Outhwaite, C.L., Hall, J., Dennis, E.B., Powney, G.D., Coomber, F., Pearce-Higgins, J.W., Dolman, S.J., Hayhow, D.B., Mathews, F., Eaton, M.A., Bedford, J., Stanbury, A.J., McQuatters-Gollop, A., Haysom, K., Johns, D.G., Hatfield, J.H., Burns, F., Bailey, N., Noble, D.G., Kirby, W.B.   +27 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

State Library of Ohio newsletter

, 2007
Monthly; Electronic access as of Jan. 23, 2006: Jan. 2003-; Title from index screen (viewed Jan. 23, 2006).; No issues published Nov. 2005-Feb.
State Library of Ohio.
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Новые данные об адвентивных видах сосудистых растений Республики Бурятия

Turczaninowia, 2016
Приведены сведения о новых местонахождениях Sinapis alba L., Hesperis pycnotricha Borbas et Degen, Armoracia rusticana Gaertn., Mey. et Scherb., Fragaria moschata (Duchesne) Weston., Rosa rugosa Thunb., Impatiens parviflora DC., Viola tricolor L.
A. V. Sutkin, E. G. Martusova, A. S. Krasnopevtseva, V. M. Krasnopevtseva   +3 more
doaj  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source