Results 51 to 60 of about 5,297,982 (312)
Stages and organization of state strategic development planning in the field of medical tourism
Економіка, управління та адмініструванняOne of the key conditions for successful state strategic planning in any industry is a clear definition of the stages of strategy development. Having analyzed the scientific literature and current regulatory legal acts, it was found that there is no ...
T.K. Gushcha
doaj +1 more source
Problem aspects and mechanisms of state management the development of the housing fund in Ukraine
Innovation and Sustainability, 2023 In the study, the attention to the problems of formation and implementation of the state housing policy, in particular in the part of the development of the country's housing stock, is updated. The purpose of the study was to identify problematic aspects,
T. Vasyltsiv, O. Rudkovsky
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Reinventing Alternative Education: An Assessment of Current State Policy and How to Improve It [PDF]
, 2010 This report identifies seven model policy elements that states should incorporate in order to develop and improve alternative pathways for struggling students and former dropouts.
Adria Steinberg +3 more
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Высшее образование в России, 2021 The article analyzes the transformation of higher education system in Turkmenistan. The aim of the research is to evaluate the prospects of Russian higher education export to Turkmenistan taking into account the peculiarities of Turkmen higher education
A. M. Pogorelskaya
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Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
Quantum-enhanced reinforcement learning for finite-episode games with discrete state spaces
, 2017 Quantum annealing algorithms belong to the class of metaheuristic tools, applicable for solving binary optimization problems. Hardware implementations of quantum annealing, such as the quantum annealing machines produced by D-Wave Systems, have been ...
Compostella, Gabriele +3 more
core +2 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source