Results 91 to 100 of about 27,759,159 (289)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

2012 Primary and general election election calendar [PDF]

, 2012
This document from the South Carolina State Election Commission is a calendar of 2011 and 2012 general and primary elections that are held throughout the state.
South Carolina State Election Commission
core  

Quantum period finding using one-qubit reduced density matrices

Physical Review Research
The quantum period-finding (QPF) algorithm can compute the period of a function exponentially faster than the best-known classical algorithm. In standard QPF, the output state has a primary contribution from r high-probability bit strings, where r is the
Marco Bernardi
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

A randomised controlled pilot trial protocol for patient led cognitive gamified training during haemodialysis

Scientific Reports
Disruptions in cognitive function have been reported in individuals undergoing haemodialysis and those with chronic kidney disease. This pilot study protocol primarily assesses the feasibility and acceptability of using mobile cognitive gaming apps for ...
Murat Aksoy, Samantha Hunter, Aziz U. R. Asghar, Sunil Bhandari   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

South Carolina election calendar for 2010 primary and general election [PDF]

, 2010
This document from the South Carolina State Election Commission is a calendar of the 2010 general and primary elections that are held throughout the state.
South Carolina State Election Commission
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Cognitive Environmental Load Design: Calibrating What Buildings Require of Their Occupants

Buildings
Building assessment asks what an environment offers its occupants. It rarely asks what the environment requires from them. Yet perceiving, interpreting, navigating and adapting to a space consumes attention, working memory and self-regulatory effort that
Federica Lippi, Fabrizio Capaccioli, Daniele Guglielmino, Alessandro Miani, Massimiliano Mandarini, David Mariani, Rita White, Enrico Greco   +7 more
doaj   +1 more source