Results 181 to 190 of about 17,396,741 (241)

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

open access: yesAdvanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu   +6 more
wiley   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

open access: yesAdvanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao   +5 more
wiley   +1 more source

Recapitulating In Vivo Pharmacokinetics and Size‐Dependent Nanomedicine Delivery in a Microfluidic Platform

open access: yesAdvanced Science, EarlyView.
A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang   +5 more
wiley   +1 more source

Impacts of Revenue Diversification and Revenue Elasticity on State Fiscal Health

Public Finance and Management, 2019
Revenue diversification and elasticity of the revenue portfolio are important characteristics of a revenue structure. Using state financial data from 2007–2012, this study identifies the different impacts of revenue diversification and revenue portfolio elasticity on the fiscal health of US states.
Wenli Yan
exaly   +2 more sources

State Revenue Shortfalls

The American Journal of Economics and Sociology, 1993
Abstract. The budgetary alternatives available to and employed by states to deal with budgetary shortfalls in the early 1980's are examined. The study suggests it may be preferable for states to consider relaxing the self‐imposed requirements of an annually balanced budget.
Braun, Bradley M.   +2 more
openaire   +2 more sources

State Revenue Cyclicality [PDF]

open access: possibleNational Tax Journal, 2004
How are major state revenue sources affected by the business cycle? Could changing the mix of taxes mitigate the severity of cyclical budget problems? This paper examines issues in estimating and interpreting the short-run elasticity of taxes with respect to personal income.
openaire   +1 more source

Oil Revenues and the State

2020
Oil revenues are becoming increasingly crucial to the political economy of West Africa. Both oil-rich and oil-scarce countries in the subregion are generating funds from the intense oil exploration and drilling activities taking place right across the West African coastline.
openaire   +1 more source

Metrology and the State: Science, Revenue, and Commerce

Science, 2004
“Natural measures of quantity, such as fathoms, cubits, inches, taken from the proportion of the human body, were once in use with every nation,” taught Adam Smith in his lecture “Money as the measure of value and medium of exchange,” delivered in 1763.
openaire   +2 more sources

Separation of State and Local Revenues

The ANNALS of the American Academy of Political and Social Science, 1915
The history of American state finance in the last thirty years reveals two major movements, one against excessive uniformity, the other against excessive decentralization. It has been found on the one hand that a uniform rate of taxation cannot successfully be applied to all forms of property, and we have the irresistible movement for classification of
openaire   +1 more source

Revenue Potential of State Lotteries

Public Finance Quarterly, 1987
The debate concerning whether to institute a lottery is hampered in many states by a lack of objective current estimates of potential revenue. The purpose of this study is to provide estimates by type of game based on the experiences of those states that already have lotteries.
openaire   +1 more source

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