Results 31 to 40 of about 47,569 (240)

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Widening fiscal deficit in Maharashtra state: causes and concerns [PDF]

Public and Municipal Finance, 2018
Maharashtra is highly urbanized and economically developed state in India. But now the growth rate is declining, and debt burden has increased in the state. CAGR has been used to examine the impact of FRBM act on fiscal deficit in the state. The RBI data
Sanjay Rode
doaj   +2 more sources

IMPACT OF ENVIRONMENTAL ADVERTISING ON CUSTOMERS’ PATRONAGE DECISION IN NIGERIA BANKS [PDF]

Oradea Journal of Business and Economics
This research study examined the impact of Environmental Advertising on Customer’s Patronage Decision in Nigerian Banks. The survey research method was engaged for the purpose of this research study.
Oyebisi IBIDUNNI, Stephen IBIDUNNI, Adetayo AFISANWO   +2 more
doaj   +1 more source

INFLUENCE OF TECHNOLOGY ADOPTION ON TAX AUDIT IN OSUN STATE, NIGERIA

Хабаршысы. Экономика сериясы, 2021
This study examined the influence of technology adoption on tax audit in Osun State. This work used the Survey research design, and the source of data was primary which was generated by the admin-istration of well-structured questionnaire
A.O. Adebayo, J.K. Olowookere, M.O. Oyekanmi   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Impact of WTO Accession on Agriculture Sustainable Development in the Russian Federation

Visegrad Journal on Bioeconomy and Sustainable Development, 2014
In the globalized context of the modern world, the phenomenon of regional integration is one of the most significant factors influencing every aspect of social and economic development of the society.
Garnik Sergei, Sokolnikova Olga
doaj   +1 more source

State General Revenues and Expenditures in Florida

EDIS, 1969
This is EDIS document FE366, a publication of the Department of Food and Resource Economics, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL.
Mulkey, David, Cothran, Henry
openaire   +6 more sources

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source