Results 81 to 90 of about 14,415,212 (341)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Security proof of a three-state quantum key distribution protocol without rotational symmetry [PDF]

open access: yes, 2006
Standard security proofs of quantum key distribution (QKD) protocols often rely on symmetry arguments. In this paper, we prove the security of a three-state protocol that does not possess rotational symmetry.
C. H. Bennett   +10 more
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

DEVELOPMENT OF A COMPREHENSIVE INDICATOR FOR DIAGNOSING MASSIVE MISSILE STRIKES

open access: yesСучасні інформаційні системи
Objective. Enhancing the efficiency of diagnosing the threat level of massive missile strikes by developing a comprehensive indicator. Methodology. The study examines the process of developing a comprehensive indicator based on a dataset of massive ...
Oleksandr Laktionov   +4 more
doaj   +1 more source

Safety of political communication in modern Russia

open access: yesВестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2013
The article analyzes transformation of the new threat in the information area. The author requests for discussion the various models of information security of Russia in the modern world.
Morozov Ilya Leonidovich
doaj   +1 more source

Economic impact of organised crime to state security

open access: yesПроблеми Законності, 2020
Organised crime is changing and becoming increasingly diverse in its methods, group structures and impact on society. This article aims to research, on the one hand, the impact of organized crime on state’s economy, on the other hand – to analyse the ...
Aurelija Pūraitė
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Political Pragmatism of Empire. [Book Review: Münkler, H. Empire. The Logic of Domination over the World: from Ancient Rome to the United States [Text] / Herfried Münkler ; Translated from German by L. V. Lannik, edited by T. A. Grablevsky

open access: yesВестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2015
This publication is a review of Herfried Münkler’s book “Empire: The logic of domination over the world - from Ancient Rome to the United States”, published in translation from German language in 2015. The reviewer describes the specifics of publication,
Kuznetsov Igor Ivanovich
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

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