Results 111 to 120 of about 5,341,587 (303)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

State and local taxation [PDF]

open access: yes
State and local taxation comprises those taxes that are collected at the sub-federal government levels in order to finance state and local public services, assigning discretion in the determination of rates and bases of these taxes to sub-federal ...
Friedrich Schneider, Lars P Feld
core  

Community Efforts to Expand Dental Services for Low-Income People [PDF]

open access: yes, 2008
Examines low-income patients' limited access to dental care, as well as state and community efforts to expand services, including changing Medicaid and State Children's Health Insurance Program reimbursement rates and licensing laws for preventive ...
Johanna R. Lauer   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Acute mastoiditis caused by Klebsiella pneumoniae carbapenemase (KPC) producing bacteria – an atypical cause

open access: yesGMS Hygiene and Infection Control
Aim: The aim of this report is to present a rare case of acute mastoiditis caused by Klebsiella (K.) pneumoniae carbapenemase (KPC) producing bacteria. Methods: The following report describes a 78-year-old immunosuppressed female who was hospitalized ...
Aristos Aristodimou   +4 more
doaj   +1 more source

State Library of Iowa Strategic Plan FY08-FY11 [PDF]

open access: yes, 2008
Mission: The State Library advocates for Iowa libraries & promotes excellence & innovation in library services in order to provide statewide access to information for all ...

core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Highlights of Fifteenth Day Enrollment for the Summer Term 2014 [PDF]

open access: yes, 2014
This item contains information on student enrollment. It includes information on such topics as enrollment by campus, credits per student, and enrollment by student ...
Ohio State University. Enrollment Services - Analysis and Reporting
core   +3 more sources

Priming for Advocacy: Revitalizing A 35-Year-Old Lecture Series

open access: yesMarketing Libraries Journal, 2020
Academic libraries face unique challenges by being a part of their larger institutions, such as a lack of visibility across campus. One solution to these challenges is advocacy, with one tool being an annual lecture series.
Broeder, Kathleen, Lanners, Emma
doaj  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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