Results 71 to 80 of about 6,001 (210)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Quantifying spontaneous infant movements using state-space models

Scientific Reports
Over the first few months after birth, the typical emergence of spontaneous, fidgety general movements is associated with later developmental outcomes.
E. Passmore, A. K. L. Kwong, J. E. Olsen, A. L. Eeles, J. L. Y. Cheong, A. J. Spittle, G. Ball   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

OpenMamba: Introducing State Space Models to Open-Vocabulary Semantic Segmentation

Applied Sciences
Open-vocabulary semantic segmentation aims to label each pixel of an image based on text descriptions provided at inference time. Recent approaches for this task are based on methods which require two stages: the first one uses a mask generator to ...
Viktor Ungur, Călin-Adrian Popa
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Resource-efficient network attack detection using selective State Space Models

Научно-технический вестник информационных технологий, механики и оптики
The spread of vulnerable Internet of Things devices leads to an increase in the number of attacks on them, which requires the development of accurate and resource-efficient detection methods.
E. O. Zdornikov, I. Yu. Popov
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Parameter-coupled state space models based on quasi-Gaussian fuzzy approximation

Scientific Reports
The accuracy of a fuzzy system’s approximation is closely tied to the performance of fuzzy control systems design, while this system’s interpretability depends on the description of a mechanical model using human language.
Yizhi Wang, Fengyuan Ma, Xiaomin Tian, Weina Chen, Yang Zhang, Shanshan Ge   +5 more
doaj   +1 more source