Results 81 to 90 of about 32,904 (306)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Load Balancing for Future Internet: An Approach Based on Game Theory

open access: yesJournal of Applied Mathematics, 2014
In recent years, countries all over the world consider the future internet as the country’s strategic development directions, so projects about future internet have been launched by these countries.
Shaoyi Song, Tingjie Lv, Xia Chen
doaj   +1 more source

Unstructured mesh generation based on Parallel Virtual Machine in cyber-physical system

open access: yesEURASIP Journal on Wireless Communications and Networking, 2019
A parallel unstructured mesh generation technique is proposed based on the built-in cyber-physical system (CPS) of Parallel Virtual Machine context. A static load-balancing strategy for computational domain decomposition is firstly presented in the paper.
Hao Dong   +3 more
doaj   +1 more source

Dynamic and static load balancing using PVM

open access: yes, 1995
This thesis presents both dynamic and static load balancing of processor work using the Parallel Virtual Machine (PVM) distributed computing environment.
Gray, William Wayne
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Criteria for the Static Balancing of Compliant Mechanisms

open access: yes, 2010
Compliant mechanisms achieve their mobility through the deformation of their members, this means that part of the energy transmitted from the input to the output of the mechanisms will be stored in the mechanisms as strain energy.
Just L. Herder, Juan A. Gallego
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Optimal static balancing of a spatial palletizing robot.

open access: yes, 2015
Static balancing is often used in industrial applications in order to reduce the actuator efforts required during the machine operations. Literature offers a number of methods to study static balancing and to define positions and features of the ...
CARRABOTTA, ROBERTO   +3 more
core  

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Static Load Balancing on Heterogeneous Systems Containing CPU and GPU

open access: yes, 2018
Scientific codes are usually highly parallelised and executed on heterogeneous architectures. Nowadays, it is common to use graphics accelerators (GPUs) to speed up data-parallel algorithms, and in the meantime, the already existing CPUs can help in this
Szénási, Sándor, Sandor Szenasi
core   +1 more source

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