Results 221 to 230 of about 10,938,300 (390)

Determining the Static Characteristics of Pneumatic Muscles

, 2016
J. Takosoglu, P. Laski, S. Błasiak, Gabriel Bracha, D. Pietrala   +4 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dynamic modeling and adaptive variable constraint optimization for integrated energy systems based on double-loop framework. [PDF]

Sci Rep
Wei Z, Dong X, Jia B, Li F, Sun B.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Control mechanism of the surrounding rock structure of multisection stopes in steeply dipping coal seams under overburden transient changes excitation. [PDF]

Sci Rep
Wu Y, Huangfu J, Luo S, Tang Y, Yan Z, Tian C, Wang T.   +6 more
europepmc   +1 more source

Evolutionary Laws of Static Mechanical Characteristics of Surrounding Rock Mass with Thin and Hard Roof Under Cyclic Loading

Wei Li, Liyuan Yu, Jiwen Bai, Jie Zhang
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Preparation of ZnO/PVA flexible piezoelectric films for sensing dynamic-static superimposed loads under varying temperatures. [PDF]

Sci Rep
Chen S, Li J, Yang W, Rong W.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Comparative evaluation of static and dynamic 4D dose recalculations in pencil beam scanning proton therapy for oesophageal cancer. [PDF]

Phys Imaging Radiat Oncol
Carizzoni LA, Cherchik A, Li X, Lomax A, Zhang Y.   +4 more
europepmc   +1 more source