Results 161 to 170 of about 3,634 (300)

Flexural behaviour of RC shear wall using enhanced finite element model. [PDF]

Sci Rep
Nasr O, Moustafa A, Ghallab AH.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Design and Analysis of a Two-Degree-of-Freedom Inertial Piezoelectric Platform. [PDF]

Materials (Basel)
Chang Q, Xu Y, Deng X, Liu X, Zhu L, Li J, Liu Y.   +6 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Evaluation of Er:YAG, Er,Cr:YSGG and diode lasers irradiation on radicular dentine fatigue strength using modified endodontic laser tips. [PDF]

Biomater Investig Dent
Sippus JH, Capitanio M, Mutluay MM, Franzen R, Tezvergil-Mutluay A.   +4 more
europepmc   +1 more source

Synthesis of parallel flexure stages with decoupled actuators using sum, intersection, and difference of screw systems

Parallel flexure systems (PFS) are used in high-precision positioning systems for a wide range of scientific, medical, and industrial applications. The controllability of the flexure system is optimized when actuators are decoupled and the output of any ...
Gallardo, Alejandro Gaston, Pucheta, Martín Alejo   +1 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Recent Advances in the Design, Modeling, and Control of Flexure-Based Nanopositioning Stages. [PDF]

Micromachines (Basel)
Liu Y.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Flexure-Based Locking Plates Can Modulate Interfragmentary Motion in Distal Femur and Diaphyseal Fractures: A Parametric Finite Element Analysis. [PDF]

J Biomech Eng
Huxman C, Updegrove G, Armstrong A, Wee H, Frecker MI, Butler J, Lewis GS.   +6 more
europepmc   +1 more source