Results 91 to 100 of about 584,893 (305)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

First results of pipe pile static load test in small laboratory scale

open access: yesMATEC Web of Conferences, 2018
Presented laboratory testing program of tubular steel piles is a part of a bigger research program which contained static load tests in full scale and numerical simulations of conducted research.
Baca Michal, Rybak Jaroslaw
doaj   +1 more source

DC-10 composite vertical stabilizer ground test program [PDF]

open access: yes
A review of the structural configuration and ground test program is presented. Particular emphasis is placed on the testing of a full-scale stub box test subcomponent and full span ground test unit.
Palmer, J. M., Jr.   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Bearing Capacity of Precast Concrete Joint Micropile Foundations in Embedded Layers: Predictions from Dynamic and Static Load Tests according to ASTM Standards

open access: yesInfrastructures
In this paper, joint precast piles with a cross-section of 400 × 400 mm and a pin-joined connection were considered, and their interaction with the soil of Western Kazakhstan has been analyzed.
Abdulla Omarov   +6 more
doaj   +1 more source

Collection of in-Field Impact Loads Acting on a Rugby Wheelchair Frame

open access: yesProceedings, 2018
This work was included in a wider project oriented to the improvement of residual neuromuscular skills in disabled athletes playing wheelchair rugby: the wheelchair rugby Italian national team was involved and tests allowed to analyse the impact loads on
Francesco Bettella   +2 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Fracture control plan for propellant and pressurant tanks [PDF]

open access: yes
To assure the functional integrity of the GLL-RPM fuel and pressurized gas tank, all activities during entire lifetime of the tank, from manufacture to the end of the mission, must be monitored. Specifications are given for all procedures which influence

core   +1 more source

The Static and Fatigue Behaviour of Through-Bolt Shear Connectors in Steel-Precast Composite Bridge Girders [PDF]

open access: yes, 2018
Increasing demand for the rapid and economically efficient construction of bridges has encouraged engineers to employ the use of accelerated bridge construction through modular assembly.
Balkos, Kyle, Daniel
core  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Home - About - Disclaimer - Privacy