Results 111 to 120 of about 584,893 (305)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Civil and Environmental EngineeringTechnological procedures related to the possession of tracks are often under heavy time constraints. Therefore, the attempts to apply dynamic load tests in the process of diagnostics of implemented construction works on modernised sections of railway ...
Ižvolt Libor +2 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Effect of outdoor exposure at ambient and elevated temperatures on fatigue life of Ti-6Al-4V titanium alloy sheet in the annealed and the solution treated and aged condition [PDF]
Specimens of Ti-6Al-4V titanium alloy sheet in the annealed and the solution-treated and aged heat-treatment condition were exposed outdoors at ambient and 560 K (550 F) temperatures to determine the effect of outdoor exposure on fatigue life. Effects of
Phillips, E. P.
core +1 more source
Analisis Kekuatan Struktur Kereta Barang “Flat Wagon” = Strength Analysis Of Flat Wagon Structures [PDF]
, 2014 This paper describes strength analysis for the flat wagon. The analysis is conducted by experiment methods using testing the flat wagon prototype with static loads such as vertical load, compression load, twist load, jacking load, and combination of them.
Anwar, A. (Anwar), ruhimat, A. (Ade)
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
BuildingsThis paper presents an analysis of long, large-diameter bored piles’ behavior under static and dynamic load tests for a megaproject located in El Alamein, on the northern shoreline of Egypt.
Nagwa Elsakhawy +3 more
doaj +1 more source
Test stand for Titan 34D SRM static firing [PDF]
An existing liquid engine test stand at the AF Astronautics Laboratory was refurbished and extensively modified to accommodate the static firing of the Titan 34D solid rocket motor (SRM) in the vertical nozzle down orientation.
Glozman, Vladimir, Shipway, George
core +1 more source