Results 51 to 60 of about 584,893 (305)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Modal deflection method for bridge load testing: a practical alternative to static load tests

Građevinar
This study investigated the effectiveness of modal deflection testing as a substitute for static load tests, focusing on the separation of the Ji-Jiao railway separated overpass.
Shukun Li, Sheng Qi, Ruofan Zhao, Xingjun Qi, Sanpeng Cao   +4 more
doaj   +1 more source

Research on Load Torque of Robot Reducer Acceleration Fatigue Tests Based on Adams

Jixie chuandong, 2023
Accuracy and fatigue life are important factors restricting the development of domestic robot reducers. In order to improve the efficiency of fatigue life test, it is very important to select appropriate load torque for accelerated life test.
Chen Lei, Tong Guiying, Mu Yinyin, Qiao Guipeng   +3 more
doaj  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Interpretation of the Pile Static Load Test Using Artificial Neural Networks

Buildings
This study presents a novel approach for interpreting static load tests (SLT) of piles using Artificial Neural Networks (ANNs) integrated with the Meyer and Kowalow load-settlement mathematical model.
Artur Sławomir Góral, Marek Lefik
doaj   +1 more source

Research on Bearing Characteristics of Open-Ended Pipe Piles under Static Load

Advances in Civil Engineering, 2021
The accurate estimate of the ultimate bearing capacity of a single pile in the vertical direction is an important issue in the design of the pile foundation. This paper presents a static test on a single-pile model. The test was performed through a large-
Haibao Feng, Xingke Dai, Shuiyue Chen, Jianwei Chen   +3 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

An Experimental Study on Determination of Crack Propagation Energy of Rock Materials Under Dynamic Impact and Static Loading Conditions

Hittite Journal of Science and Engineering, 2019
The Charpy impact test, a widely applied impact strength determination test for various materials such as metals, polymers and cementitious materials was performed to evaluate the crack propagation energy of 13 different granite type rock materials ...
Eren Komurlu
doaj   +1 more source